From the FDA Drug Label
In Adults, 750 to 1750 mg/day in divided doses every 8 to 12 hours The adult dose of amoxicillin for dental abscess is 750 to 1750 mg/day in divided doses every 8 to 12 hours 1.
From the Research
For a dental abscess in an adult who is allergic to clavulanic acid in Augmentin, amoxicillin alone can be prescribed at a dose of 500 mg three times daily for 5-7 days, as supported by the most recent study 2. This regimen provides adequate coverage against most oral bacteria causing dental infections. If the infection is more severe, the dose may be increased to 875 mg twice daily. It's essential to take the full course of antibiotics even if symptoms improve before completion. Amoxicillin works by inhibiting bacterial cell wall synthesis, and while clavulanic acid (the component you're allergic to) enhances amoxicillin's effectiveness against certain resistant bacteria, amoxicillin alone is often sufficient for dental infections. Some key points to consider:
- The effectiveness of amoxicillin against common bacteria causing odontogenic infections, such as Enterococcus faecalis and Staphylococcus aureus, has been demonstrated in studies 3.
- The choice of antibiotic should be guided by the severity of the infection and the patient's allergy history, with clindamycin being an alternative option in some cases 4.
- Dental treatment to address the source of infection is the primary factor in the successful management of dentoalveolar abscesses, with antibiotics playing an adjunctive role 2. Remember that antibiotics are an adjunct to dental treatment - definitive management requires addressing the source of infection through dental procedures. If symptoms worsen or don't improve within 48-72 hours, contact your healthcare provider as alternative antibiotics like clindamycin may be needed.