From the Guidelines
For contact lens use, the best antibiotic choice is not explicitly stated in the provided evidence, but based on the context of skin and soft tissue infections, fluoroquinolones such as moxifloxacin or gatifloxacin are typically effective against common pathogens. However, the provided evidence focuses on skin and soft tissue infections rather than contact lens-related infections. Considering the most recent and highest quality study, the 2014 update by the Infectious Diseases Society of America 1 recommends amoxicillin-clavulanate, doxycycline, or fluoroquinolones like moxifloxacin for skin and soft tissue infections, which could be relevant for infections related to contact lens use. Some key points to consider:
- The choice of antibiotic depends on the type of infection and the suspected pathogens.
- Fluoroquinolones like moxifloxacin have broad-spectrum activity and are effective against many common pathogens.
- It's essential to consult an eye care professional for proper diagnosis and treatment of contact lens-related infections.
- While using antibiotic drops, it's crucial to avoid wearing contacts until treatment is complete and the doctor approves resuming use. The provided evidence does not directly address contact lens-related infections, but the general principles of antibiotic use for skin and soft tissue infections can be applied, prioritizing the use of broad-spectrum antibiotics like fluoroquinolones 1.
From the Research
Antibiotic Treatment for Complicated Urinary Tract Infections
- Ciprofloxacin is a commonly used antibiotic for treating complicated urinary tract infections (UTIs) 2, 3, 4.
- A study comparing 7-day and 14-day courses of ciprofloxacin found that both regimens were effective in treating acute pyelonephritis in women, with short-term clinical cure rates of 97% and 96%, respectively 2.
- Another study found that extended-release ciprofloxacin (1,000 mg once daily) was as effective as conventional ciprofloxacin (500 mg twice daily) in treating complicated UTIs and acute uncomplicated pyelonephritis 3.
Comparison with Other Antibiotics
- A study comparing amoxicillin-clavulanate with ciprofloxacin for the treatment of uncomplicated cystitis in women found that ciprofloxacin was more effective, with clinical cure rates of 77% versus 58% 5.
- A study comparing ciprofloxacin with amoxycillin/clavulanic acid for the treatment of chronic sinusitis found that ciprofloxacin was at least as effective, with a higher cure rate among patients with a positive initial culture 6.
Dosage and Administration
- Ciprofloxacin can be administered once or twice daily, depending on the specific formulation and treatment regimen 3, 4.
- A study comparing once-daily with twice-daily ciprofloxacin for the treatment of complicated UTIs found that the twice-daily regimen was more effective in eradicating bacteriuria 4.