What are the post-procedure instructions for a patient with a wound closed with skin glue?

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Post-Procedure Instructions for Wounds Closed with Skin Glue

Immediate Care (First 24-48 Hours)

Keep the wound completely dry for the first 24-48 hours to allow proper adhesion and initial healing. 1, 2

  • Avoid submerging the wound in water during this critical period 1
  • Brief showers may be acceptable after 24 hours only if you can keep the glued area completely dry 1
  • Do not apply any ointments, creams, lotions, or other topical products over or near the skin glue, as these will loosen the adhesive 1

Daily Monitoring Requirements

Check the wound daily for warning signs that require immediate medical attention. 1

Monitor specifically for:

  • Increasing pain, redness, swelling, or warmth around the wound 1, 2
  • Any discharge or drainage from the wound 1, 2
  • Wound edges separating or opening (dehiscence) 1
  • Pain that seems disproportionate to the injury severity, which may indicate deeper complications like infection 1, 2

Activity Restrictions

Avoid activities that place tension on the wound or cause excessive sweating for at least the first week. 1

  • Elevate the injured body part if swelling occurs to accelerate healing 1
  • Skin glue provides adequate closure for low-tension wounds, but should be used with caution in high-tension body areas 3

Duration and Natural Separation

The skin glue will naturally peel off on its own as the wound heals beneath it. 1, 4

  • For facial wounds: The glue typically remains in place for 5-7 days 1, 4
  • For body wounds (trunk, arms, legs): The glue remains for 10-14 days 1
  • Do not pick at or forcibly remove the glue 1
  • If edges begin peeling but the center remains adherent, you may trim loose edges with clean scissors rather than removing the entire application 1

Hygiene After Initial Healing Period

After 24-48 hours, you may resume normal hygiene with precautions. 1, 4

  • Gentle washing with soap and water is acceptable after the initial 24-48 hour period 4
  • Pat the area dry thoroughly after any water exposure 4
  • The glue is waterproof once fully set, but avoid prolonged water immersion 5
  • Always wash hands with soap and water or alcohol-based sanitizer before and after any wound contact 1

Emergency Warning Signs

Seek immediate medical attention if you develop any of these signs: 1

  • Fever or chills 1
  • Red streaks extending from the wound 1
  • Pus or cloudy drainage 1
  • Wound edges separating or opening 1
  • Increasing pain after the first 2-3 days (pain should be decreasing, not increasing) 1
  • Foul odor from the wound 1

Important Caveats

Be aware that skin glue has a higher risk of wound breakdown compared to sutures. 2

  • Studies show tissue adhesives have a 3.35 times higher risk of wound dehiscence compared to sutures 2
  • This risk is acceptable for appropriate low-tension wounds, but vigilant monitoring is essential 2, 3
  • The number needed to harm (one additional dehiscence) with glue versus sutures is 43 patients 2

References

Guideline

Wound Care Guidelines for Steri-Strip Use

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Skin Glue for Wound Closure

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Duration of Sterile Strips After Laceration Repair

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Easy way of gluing the skin of surgical wounds.

International journal of clinical practice, 2009

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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