What physical sign is most consistent with a sequela of an underlying eating disorder, given a 23-year-old female patient with recurrent infections on her hand and other physical findings?

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Swollen Cheeks or Jawline

The most consistent physical sign of an underlying eating disorder in this patient is swollen cheeks or jawline, which represents parotid gland enlargement from recurrent self-induced vomiting. 1, 2

Clinical Presentation: Russell's Sign

The recurrent infections along the dorsal surface of the hand over the MCP joints, with multiple scars and lesions at different healing stages, represent Russell's sign—calluses and trauma caused by repeated contact with the upper incisors during self-induced vomiting. 3 This is a pathognomonic finding for bulimia nervosa and indicates compensatory purging behavior following binge eating episodes. 3

Why Swollen Cheeks/Jawline is the Correct Answer

Parotid gland enlargement (appearing as swollen cheeks or jawline) is a direct sequela of the same purging behavior causing Russell's sign. 1, 2 The mechanism involves:

  • Repeated self-induced vomiting stimulates salivary gland hypertrophy, particularly affecting the parotid glands 4, 5
  • This creates visible bilateral swelling along the jawline and cheeks 1
  • Parotid enlargement is specifically listed as a key physical warning sign for eating disorders in multiple guidelines 1, 2

Why Other Options Are Incorrect

Good dentition and gum health would be inconsistent with eating disorders. Self-induced vomiting causes dental enamel erosion, dental caries, and poor gum health due to repeated acid exposure from gastric contents. 1, 4, 5

Limb casts for recent bone fractures could suggest osteoporosis from prolonged malnutrition and amenorrhea, but this is a long-term complication requiring months to years of illness. 1, 2 The question asks for findings most consistent with the acute presentation of Russell's sign, which indicates active purging behavior.

Thick hair with typical hairlines contradicts eating disorder sequelae. Patients typically present with alopecia, hair thinning, and fine lanugo-like hair growth on the face due to malnutrition. 1, 3

Clinical Significance

This 23-year-old female demonstrates the classic triad of bulimia nervosa:

  • Russell's sign (dorsal hand lesions from self-induced vomiting) 3
  • Parotid gland enlargement (swollen cheeks/jawline) 1, 2, 4
  • Young female demographic (eating disorders are more common in females) 6

Recognition of these dermatologic and oral-facial signs enables early diagnosis and treatment, which is critical given that bulimia nervosa carries a 76.3% lifetime rate of depression and significantly elevated suicide risk. 6

Essential Next Steps

  • Perform comprehensive evaluation including vital signs, orthostatic measurements, and BMI calculation 2, 7
  • Order complete blood count and comprehensive metabolic panel to assess for hypokalemia and hypochloremic alkalosis from purging 8, 2, 7
  • Obtain electrocardiogram to evaluate for QTc prolongation, which predicts sudden cardiac death risk 2, 7
  • Assess for dental erosion, xerostomia, and other oral manifestations of chronic vomiting 4, 5
  • Screen for comorbid depression, anxiety, and suicidality 2, 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Diagnostic Evaluation of Anorexia Nervosa

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Oral signs and symptoms in the diagnosis of bulimia.

Journal of the American Dental Association (1939), 1986

Guideline

Treatment Guidelines for Eating Disorders

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Laboratory Tests for Eating Disorder Referral

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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