Niftaz (Nifurzide) Renal Safety
I cannot provide a definitive recommendation on the renal safety of Niftaz (nifurzide) because none of the provided evidence addresses this specific medication. The evidence exclusively discusses other drugs including bisphosphonates, tuberculosis medications, anticoagulants, cardiovascular agents, and nifedipine (a calcium channel blocker)—but not nifurzide.
Important Clarification
Nifurzide and nifedipine are completely different medications that should not be confused:
- Nifurzide: An intestinal antiseptic/antimicrobial agent used primarily for acute diarrhea
- Nifedipine: A calcium channel blocker used for hypertension and angina
Evidence on Nifedipine (NOT Nifurzide) Renal Safety
While not answering your question, the available evidence shows that nifedipine appears to be renal-safe and may even improve renal function:
Pharmacokinetics in Renal Failure
- Nifedipine can be used without dose modification in patients with renal failure 1
- The oral plasma clearance was 1189 ± 876 ml/min with a half-life of 5.99 ± 3.05 hours in renal failure patients 1
- The pyridine metabolite is not retained in renal impairment 1
Renal Function Effects
- Nifedipine increased glomerular filtration rate by 13.3% and effective renal plasma flow by 19.6% in hypertensive patients 2
- Mean creatinine clearance remained stable or improved during 4-month treatment (initial: 31.4 ± 12.3 ml/min; final: 32.7 ± 14.4 ml/min) 1
- Renal vascular resistance decreased by 25.2% 2
What You Need for Nifurzide
To properly assess nifurzide's renal safety, you would need:
- Pharmacokinetic data on renal excretion pathways
- Clinical studies in patients with varying degrees of renal impairment
- Manufacturer prescribing information specific to nifurzide
- Post-marketing surveillance data on nephrotoxicity
Consult the specific drug monograph or prescribing information for nifurzide to determine appropriate use in renal impairment.