Differential Diagnosis for 9mm Diameter Rounded Opacity with Dense Central Calcifications and Laminations
- Single most likely diagnosis
- Pulmonary hamartoma: This is the most likely diagnosis due to the characteristic appearance of a rounded opacity with dense central calcifications and laminations in the periphery, which is often described as a "popcorn" calcification pattern.
- Other Likely diagnoses
- Granuloma: A granuloma, such as one caused by histoplasmosis or tuberculosis, can present with calcifications and may have a similar appearance, although the calcifications are typically more peripheral and less dense.
- Pulmonary arteriovenous malformation (AVM): While less common, a pulmonary AVM can present with a rounded opacity and may have calcifications, although these are typically phleboliths and not as dense as those seen in a hamartoma.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed)
- Pulmonary malignancy with calcification: Although less common, certain pulmonary malignancies such as adenocarcinoma or carcinoid tumors can present with calcifications. It is crucial to consider this diagnosis to avoid missing a potentially treatable cancer.
- Hydatid cyst: In endemic areas, a hydatid cyst can present with calcifications and a rounded opacity. This diagnosis is critical to consider due to the potential for serious complications if left untreated.
- Rare diagnoses
- Pulmonary osteoma: A rare benign tumor that can present with a rounded opacity and dense calcifications.
- Amyloidosis: A rare condition that can cause pulmonary nodules with calcifications, although this is typically seen in the context of systemic disease.