Brand Name of Betamethasone Sodium Phosphate
The brand name of Betamethasone Sodium Phosphate is Celestone Phosphate, and when combined with betamethasone acetate in a dual-acting suspension, it is marketed as Celestone Soluspan or Celestone Chronodose. 1, 2, 3
Available Formulations
Single-Agent Betamethasone Phosphate
- Celestone Injection contains betamethasone phosphate equivalent to 8 mg betamethasone in solution form for intramuscular administration 3
- Celestone Phosphate is the brand name specifically for betamethasone sodium phosphate alone 4
Combination Products
- Celestone Soluspan is a dual-acting suspension containing both betamethasone sodium phosphate and betamethasone acetate 2, 4
- Celestone Chronodose is another formulation containing 3.1 mg/mL betamethasone acetate suspended in a solution of 4 mg/mL betamethasone phosphate 3
Pharmacokinetic Distinction
- The phosphate ester in Celestone formulations is readily absorbed with high bioavailability, while the acetate component acts as a sustained-release reservoir 3, 5
- When administered intramuscularly, betamethasone phosphate from Celestone Injection provides bioavailability as high as intravenous injection 3
- In the dual-acting Celestone Chronodose formulation, the phosphate ester is absorbed intact but betamethasone acetate is not detected in plasma, with the acetate serving as a prodrug for extended release 3, 5