From the Guidelines
It is not recommended to take iron tablets with alcohol, as alcohol can interfere with iron absorption and worsen side effects, and also due to the potential risk of liver damage and other complications associated with iron overload and alcohol consumption. According to the EASL clinical practice guidelines on haemochromatosis 1, patients with haemochromatosis should be advised to avoid or reduce alcohol consumption, especially during the iron depletion phase of treatment.
Key Considerations
- Alcohol consumption can accelerate fibrosis and increase the risk of cirrhosis, liver cancer, and liver-related mortality in patients with haemochromatosis 1.
- Iron supplementation should be avoided in patients with haemochromatosis, and iron-fortified food should be avoided where possible 1.
- Vitamin C supplementation should also be avoided, especially before iron depletion, as it can enhance non-heme iron absorption and potentially worsen iron overload 1.
- Red meat consumption should be limited, and patients with iron overload and/or liver abnormalities should avoid or consume very little alcohol 1.
Recommendations for Iron Supplementation
- If iron supplements are necessary, they should be taken with vitamin C-rich food or juice to enhance absorption, and with a meal if they cause stomach discomfort.
- For optimal absorption, iron supplements should be taken at least two hours before or after consuming alcohol.
- Patients who regularly consume alcohol and require iron supplementation should discuss this with their healthcare provider, who may recommend specific timing for their supplements or alternative formulations that might be gentler on the stomach.
From the Research
Iron Tablets and Alcohol Consumption
- There is no direct evidence in the provided studies that specifically addresses the interaction between iron tablets and alcohol consumption 2, 3, 4, 5, 6.
- However, a study from 1996 suggests that excessive alcohol consumption can affect human iron homeostasis and lead to increased hepatic iron levels 3.
- Another study from 2023 found that coffee decreased iron absorption by 54%, and coffee with breakfast decreased iron absorption by 66% 2.
- It can be inferred that substances that affect iron absorption or metabolism may interact with iron tablets, but the specific effect of alcohol on iron tablet absorption is not directly addressed in the provided studies.
- A study from 2025 discusses the diagnosis and treatment of iron deficiency, including oral iron supplements, but does not mention alcohol consumption as a factor affecting iron absorption 4.
- Studies from 2020 and 2018 discuss iron therapy in inflammatory bowel disease, including oral and intravenous iron formulations, but do not address the interaction between iron tablets and alcohol consumption 5, 6.