Can a 9-month-old infant be given Benadryl (Diphenhydramine)?

From the Guidelines

No, a 9-month-old infant should not be given Benadryl (Diphenhydramine) due to the potential toxicity and lack of established efficacy in children younger than 6 years 1.

Risks and Concerns

• The use of over-the-counter (OTC) cough and cold medications, including antihistamines like diphenhydramine, has been associated with significant morbidity and mortality in young children 1.
• There have been reports of fatalities associated with the use of diphenhydramine in children under the age of 2 years, often due to overdose or medication errors 1.
• The American Academy of Pediatrics and other organizations have advised against the use of OTC cough medications, including those containing antihistamines, in children under the age of 6 years 1.

Alternative Considerations

• Second-generation antihistamines, such as cetirizine, desloratadine, fexofenadine, levocetirizine, and loratadine, have been shown to be well-tolerated and have a good safety profile in young children 1.
• However, it is essential to consult a physician before administering any medication to a 9-month-old infant, as their dosage and treatment recommendations may vary 1.

From the FDA Drug Label

Directions • take every 4 to 6 hours, or as directed by a physician• do not take more than 6 doses in 24 hours age/dose Adults and children over 12 years of age10 mL (25 mg) to 20 mL (50 mg) Children 6 to under 12 years of age10 mL (25 mg) Children under 6 years of ageDo not use

• The drug label explicitly states do not use for children under 6 years of age.
• A 9-month-old infant is under 6 years of age.
• Therefore, no, a 9-month-old infant should not be given Benadryl (Diphenhydramine) 2.

From the Research

Diphenhydramine Administration to Infants

• The administration of diphenhydramine (Benadryl) to infants is a serious matter that requires careful consideration due to the potential for adverse effects 3, 4, 5, 6, 7.
• According to the studies, diphenhydramine can cause a range of symptoms in infants, including tachycardia, hallucinations, somnolence, agitation, and mydriasis 6.
• In severe cases, diphenhydramine overdose can lead to seizures, cardiac arrest, and even death, particularly in infants under 6 months of age 3, 5, 7.
• The American Academy of Pediatrics does not recommend the use of diphenhydramine in infants under 6 months of age due to the risk of adverse effects 4.

Age and Dosage Considerations

• The studies suggest that infants under 6 months of age are at higher risk of adverse effects from diphenhydramine due to their immature liver and kidney function 3, 7.
• The recommended dosage of diphenhydramine for infants is not established, and the use of this medication in infants should be approached with caution 4.
• In cases where diphenhydramine is administered to an infant, close monitoring for signs of adverse effects is crucial, and medical attention should be sought immediately if any symptoms occur 5, 6.

Specific Considerations for 9-Month-Old Infants

• While the studies do not provide specific guidance on the administration of diphenhydramine to 9-month-old infants, they do suggest that infants under 1 year of age are still at risk of adverse effects from this medication 6.
• Given the potential risks, it is essential to consult with a healthcare professional before administering diphenhydramine to a 9-month-old infant 3, 4, 5, 6, 7.