What is the dose of Breo (fluticasone furoate and vilanterol)?

From the Guidelines

The recommended dose of Breo Ellipta for adults with asthma is one inhalation of either 100/25 mcg or 200/25 mcg once daily, with the 200/25 mcg strength generally reserved for patients requiring a higher dose of the corticosteroid component. The medication is available in two strengths: 100/25 mcg and 200/25 mcg, with the first number representing fluticasone furoate (an inhaled corticosteroid) and the second number representing vilanterol (a long-acting beta-agonist) 1. For COPD patients, the recommended dose is one inhalation of the 100/25 mcg strength once daily. Key points to consider when prescribing Breo Ellipta include:

• Taking the medication at the same time each day for best results
• Rinsing the mouth after use to prevent thrush
• Not exceeding the prescribed dose, as overuse can increase the risk of side effects without providing additional benefit
• The medication works by reducing inflammation in the airways (fluticasone component) while simultaneously relaxing airway muscles to improve breathing (vilanterol component) 1. It's worth noting that the provided evidence 1 does not directly mention Breo Ellipta, but based on the general knowledge of the medication and its components, the above recommendation can be made.

From the FDA Drug Label

2.1 Recommended Dosage for Maintenance Treatment of Chronic Obstructive Pulmonary Disease The recommended dosage of BREO ELLIPTA 100/25 mcg (containing fluticasone furoate 100 mcg and vilanterol 25 mcg) is 1 actuation once daily by oral inhalation. 2.2 Recommended Dosage for Maintenance Treatment of Asthma The recommended dosage of BREO ELLIPTA 100/25 mcg (containing fluticasone furoate 100 mcg and vilanterol 25 mcg) is 1 actuation once daily by oral inhalation or BREO ELLIPTA 200/25 mcg (containing fluticasone furoate 200 mcg and vilanterol 25 mcg) is 1 actuation once daily by oral inhalation 3 DOSAGE FORMS AND STRENGTHS Inhalation powder:

• 50 mcg fluticasone furoate and 25 mcg vilanterol (50/25 mcg) per actuation
• 100 mcg fluticasone furoate and 25 mcg vilanterol (100/25 mcg) per actuation
• 200 mcg fluticasone furoate and 25 mcg vilanterol (200/25 mcg) per actuation

The dose of Breo (vilanterol) is 25 mcg per actuation, and it is administered once daily by oral inhalation in combination with fluticasone furoate. The recommended dosages are:

• 100/25 mcg (fluticasone furoate 100 mcg and vilanterol 25 mcg) for maintenance treatment of COPD and asthma in adult patients and pediatric patients aged 12 years and older
• 200/25 mcg (fluticasone furoate 200 mcg and vilanterol 25 mcg) for maintenance treatment of asthma in adult patients
• 50/25 mcg (fluticasone furoate 50 mcg and vilanterol 25 mcg) for maintenance treatment of asthma in pediatric patients aged 5 to 11 years 2

From the Research

Dose of Breo

• The dose of Breo (fluticasone furoate/vilanterol) is mentioned in several studies as follows:
  • 200/25 μg once-daily 3
  • 100/25 mcg once-daily 4, 5, 6
  • 100 μg fluticasone furoate and 25 μg vilanterol once-daily 6
• These studies suggest that the dose of Breo can vary, but the most commonly mentioned dose is 100/25 mcg once-daily.

Studies Mentioning Breo Dose

• A study published in 2015 compared the effectiveness of once-daily fluticasone furoate/vilanterol 200/25 μg with twice-daily fluticasone propionate/salmeterol 500/50 μg in patients with asthma-COPD overlap syndrome 3.
• Another study published in 2014 compared the lung function effects of fluticasone furoate/vilanterol 100/25 mcg once-daily with those of twice-daily fluticasone propionate/salmeterol 250/50 mcg in patients with COPD 4.
• A 2019 study evaluated the use of fluticasone furoate + vilanterol for the treatment of chronic obstructive pulmonary disease (COPD) and mentioned the dose as 100/25 mcg once-daily 5.
• A 2016 study published in The New England Journal of Medicine mentioned the dose of fluticasone furoate-vilanterol as 100 μg and 25 μg once-daily 6.