CAPVAXIVE Vaccine Preparation
I cannot provide specific guidance on whether to shake CAPVAXIVE before administration because the provided evidence does not contain the FDA drug label or manufacturer's package insert for CAPVAXIVE, which is the definitive source for preparation instructions.
Critical Principle for Vaccine Preparation
Always follow the manufacturer's package insert exactly as written for vaccine preparation, including whether to shake, gently swirl, or avoid agitation entirely. 1
Why This Matters
Adjuvanted Vaccines Require Specific Handling
- Vaccines containing aluminum adjuvants (such as aluminum phosphate or aluminum hydroxide) typically require gentle agitation to resuspend the adjuvant that has settled during storage 1
- Failure to properly mix adjuvanted vaccines can result in administering an incorrect dose of antigen or adjuvant 1
- However, excessive or vigorous shaking can potentially damage certain vaccine components 1
Consequences of Improper Preparation
- Deviating from manufacturer's reconstitution and preparation instructions can render vaccines impotent and result in inadequate immune response 1
- Mishandled vaccine may appear identical to properly prepared vaccine, making errors difficult to detect 1
What You Must Do
Consult the CAPVAXIVE package insert immediately before administration - the insert will specify exact preparation steps including:
- Whether to shake vigorously, gently swirl, or invert
- How many times to agitate
- Visual inspection criteria after mixing
- Any specific warnings about preparation 1
When in doubt about appropriate vaccine handling, contact the manufacturer directly before administering the vaccine 1