Generic Name of Eliquis
The generic name of Eliquis is apixaban. 1
Drug Classification and Mechanism
- Apixaban is an oral direct factor Xa inhibitor that does not require antithrombin III for its antithrombotic activity 1
- It is classified among the direct oral anticoagulants (DOACs), which also include dabigatran (a direct thrombin inhibitor), rivaroxaban, and edoxaban (both factor Xa inhibitors) 2
- The molecular formula is C25H25N5O4 with a molecular weight of 459.5, chemically described as 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 1
Brand Name and Marketing
- Apixaban is marketed under the brand name Eliquis® by Bristol-Myers Squibb and Pfizer 3, 4
- The medication is available in oral tablet formulations of 2.5 mg and 5 mg strengths 1
Clinical Context
- Apixaban has predictable pharmacodynamics and pharmacokinetics without requiring routine anticoagulation monitoring 3
- It is indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, for prophylaxis of deep vein thrombosis following hip or knee replacement surgery, and for treatment of DVT and PE 1