What is the recommended dose of Cremaffin (Diphenylmethane derivative) plus?

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Cremaffin Plus Dosing Information

Critical Notice: No Evidence Available for Cremaffin Plus

I cannot provide a recommended dose for Cremaffin Plus as none of the provided evidence addresses this medication. The evidence provided relates to entirely unrelated medications including antibiotics, chemotherapy agents, migraine treatments, and cardiac medications, but contains no information about Cremaffin (a liquid paraffin-based laxative) or any "Cremaffin Plus" formulation.

What is Cremaffin Plus?

Cremaffin Plus is typically a combination laxative product containing:

  • Liquid paraffin (mineral oil) - a lubricant laxative
  • Milk of magnesia (magnesium hydroxide) - an osmotic laxative
  • Sometimes sodium picosulfate - a stimulant laxative

General Dosing Guidance (Based on Medical Knowledge)

Since no guideline or drug label evidence was provided, I can only offer general medical knowledge:

Typical Adult Dosing

  • Standard dose: 10-20 mL orally at bedtime
  • Maximum: Usually not exceeding 30 mL per day
  • Duration: Should not be used for more than 1 week without medical supervision

Pediatric Considerations

  • Dosing varies significantly by age and weight
  • Generally not recommended for children under 6 years without physician guidance
  • Liquid paraffin showed better efficacy than lactulose in one pediatric study at 1 mL/kg per day 1

Important Caveats

  • Consult product labeling: Specific formulations vary by manufacturer and country
  • Avoid prolonged use: Chronic use of liquid paraffin can interfere with fat-soluble vitamin absorption
  • Contraindications: Should not be used in bowel obstruction, acute abdominal conditions, or difficulty swallowing

For accurate dosing of your specific Cremaffin Plus product, consult the package insert or prescribing information from the manufacturer.

References

Research

A comparative study: the efficacy of liquid paraffin and lactulose in management of chronic functional constipation.

Pediatrics international : official journal of the Japan Pediatric Society, 2005

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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