From the Guidelines
Livodox Plus tablet is recommended for patients with liver issues, particularly those with fatty liver disease, as it helps reduce inflammation and promote liver cell regeneration, with a typical dosage of one tablet taken once or twice daily. The active ingredients in Livodox Plus, such as silymarin and ursodeoxycholic acid, have been shown to improve liver function by reducing oxidative stress and enhancing bile flow, as seen in studies such as 1 where interventions like RO5093151 and Obeticholic Acid and Statins resulted in improvements in liver fat and enzyme levels. Some key benefits of Livodox Plus include:
- Reducing inflammation in the liver, which is crucial for preventing further damage and promoting healing
- Promoting regeneration of liver cells, which can help improve liver function over time
- Protecting hepatocytes from further damage, which can help prevent the progression of liver disease
- Enhancing bile flow, which aids in detoxification and can help reduce the risk of liver damage
- Strengthening cell membranes against damage, which can help protect the liver from further injury It is essential to note that while Livodox Plus can be beneficial for many liver conditions, it should be used as part of a comprehensive approach that includes lifestyle modifications, such as reducing alcohol consumption, maintaining a healthy weight, and following a balanced diet low in processed foods and high in fruits and vegetables, as recommended in studies like 1. Patients with severe liver disease should not rely solely on supplements but should be under medical supervision for proper management of their condition, as indicated by the various studies listed in 1, which highlight the importance of a multifaceted approach to managing liver health.
From the Research
Liver Issues and Indications for Livodox Plus Tablet Usage
- Livodox plus tablet is used to treat liver issues, particularly nonalcoholic fatty liver disease (NAFLD) 2, 3, 4.
- The tablet contains ursodeoxycholic acid (UDCA), which has been shown to have a beneficial effect on dyslipidemia and atherosclerotic cardiovascular disease (ASCVD) risk due to its antioxidant properties 2.
- UDCA has been found to improve liver function tests, lipid profile, and hepatic steatosis, and has a positive effect on carotid intima-media thickness (CIMT) and 10-year ASCVD risk in patients with NAFLD 2, 3.
Mechanism of Action
- UDCA normalizes liver enzymes, improves lipid profile, and reduces hepatic steatosis independent of weight loss 2.
- Omega-3 fatty acids, which may be included in Livodox plus tablet, have been shown to have a beneficial effect on liver lipid metabolism and inflammation in NAFLD patients 5.
- UDCA and omega-3 fatty acids may work together to ameliorate liver disease in NAFLD patients by reducing liver triglyceride and improving inflammatory pathways 3, 5.
Clinical Evidence
- A systematic review and meta-analysis found that UDCA significantly reduced alanine transaminase (ALT), aspartate transaminase (AST), and gamma-glutamyl transferase (GGT) levels in NAFLD patients 3.
- Another study found that UDCA improved liver function tests, insulin sensitivity, and glucose tolerance in morbidly obese patients with NAFLD 4.
- A review of the literature found that bile acids, including UDCA, were associated with improved normalization of liver biochemistry in non-alcoholic fatty liver disease, autoimmune hepatitis, and hepatitis B and C infections 6.