Focalin (Dexmethylphenidate) Dosing Recommendations
The maximum total daily dose of immediate-release Focalin is 40 mg per day, administered in divided doses throughout the day, as recommended by the American Academy of Child and Adolescent Psychiatry. 1
Dosing Strategy
Immediate-Release Formulation
- Maximum daily dose: 40 mg total per day for patients taking multiple daily doses 1
- The medication should be divided into multiple doses throughout the day (typically 2-3 times daily) 1
- Dosing should be carefully titrated based on individual response and tolerability 1
Extended-Release Formulation
- The 40 mg maximum applies specifically to immediate-release formulations, NOT extended-release products 1
- Extended-release formulations have different dosing parameters and should not be assumed to follow the same maximum dose guidelines 1
- Lack of safety and efficacy data beyond recommended doses necessitates careful consideration when prescribing 1
When Treatment Fails
If no improvement occurs after appropriate dosage adjustment over one month, switch to an alternative stimulant or add non-pharmacological interventions. 1
Treatment Modification Algorithm
- Allow adequate trial period: one full month at optimized dose 1
- If inadequate response: consider switching to a different stimulant medication class 1
- Alternative approach: augment with behavioral interventions or other non-pharmacological strategies 1
Critical Caveats
- Do not exceed 40 mg/day for immediate-release formulations without clear evidence supporting higher doses 1
- The absence of safety data beyond recommended doses means exceeding these limits places patients at unknown risk 1
- Extended-release formulations require separate dosing considerations and should not be dosed using immediate-release guidelines 1