Caplyta (Lumateperone) Administration Timing
Caplyta should be taken once daily with food, and can be administered at any time of day that is convenient for the patient.
Dosing Schedule
- Lumateperone is administered as a single daily dose of 42 mg (one capsule), taken with food 1, 2
- The medication can be taken at any time during the day, allowing flexibility based on patient preference and lifestyle 2
Why Food Matters
- Taking Caplyta with food is essential - this was the administration method used in all clinical trials that established the drug's efficacy and safety profile 3, 2
- Food intake helps optimize drug absorption and may reduce potential gastrointestinal side effects 3
Practical Considerations
- Choose a consistent time each day that aligns with a regular meal to promote adherence 2
- Morning with breakfast, evening with dinner, or any other mealtime is acceptable - the key is consistency and taking it with food 3
- Unlike some medications that require specific timing relative to other drugs or activities, lumateperone has no such restrictions beyond the food requirement 2
Clinical Trial Evidence
- In the pivotal phase 3 trial that led to FDA approval, patients received lumateperone once daily for 4 weeks, demonstrating significant improvement in schizophrenia symptoms (PANSS total score reduction of -4.2 points vs placebo, p=0.02) 3
- The medication was well-tolerated with minimal metabolic or extrapyramidal side effects when taken as directed 3, 2