Is a right side Cervical Epidural Steroid Injection (CESI) at cervical levels 5 to 6 and 6 to 7, with anesthesia and moderate sedation, medically necessary for a patient with a diagnosis of radiculopathy (M54.12)?

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Medical Necessity Assessment for Cervical Epidural Steroid Injection

Yes, a right-sided cervical epidural steroid injection at C5-6 and C6-7 is medically necessary for this patient with cervical radiculopathy (M54.12), provided that specific clinical criteria are met and documented.

Critical Medical Necessity Criteria

Required Clinical Documentation

  • Radicular symptoms must be present and documented: The diagnosis code M54.12 (cervical radiculopathy) indicates nerve root involvement with radiating pain into the upper extremity, which is the primary indication for cervical epidural steroid injection 1, 2.

  • Conservative treatment failure must be documented: The patient must have failed at least 4-6 weeks of conservative management including physical therapy, NSAIDs, and activity modification before epidural injection is considered medically necessary 3.

  • MRI correlation is required: Advanced imaging (MRI) must demonstrate nerve root compression or disc herniation that correlates anatomically with the clinical symptoms and radicular distribution 3, 2.

Guideline-Supported Indications

  • The American Society of Anesthesiologists strongly recommends epidural steroid injections specifically for patients with radicular pain or radiculopathy as part of a multimodal treatment regimen 3, 1, 2.

  • The procedure is appropriate when there is clinical evidence of nerve root compression causing radiating arm pain, numbness, or weakness in a dermatomal distribution 1.

Mandatory Procedural Requirements

Fluoroscopic Guidance

  • Fluoroscopic guidance is mandatory for cervical epidural injections to ensure proper needle placement and minimize the risk of serious complications including spinal cord injury 3, 2, 4.

  • Epidurography (contrast injection) should be performed prior to therapeutic injection to confirm epidural placement and avoid intravascular or intrathecal injection 4.

Multi-Level Injection Justification

  • Injecting at both C5-6 and C6-7 levels is appropriate when imaging demonstrates pathology at both levels that correlates with the patient's radicular symptoms 5.

  • A single epidural injection with table positioning has been studied as an alternative approach for managing multi-level radiculopathy, though direct injection at each symptomatic level is more commonly practiced 5.

Safety Considerations and Risk Disclosure

Evidence of Safety at Upper Cervical Levels

  • Cervical epidural injections above C7-T1 are safe when performed with proper technique: A large retrospective study of 12,168 cervical epidural injections found no correlation between spinal level and complication rates, with the most common injection level being C5-6 4.

  • The study documented 129 minor complications (1.06%) and only 7 serious complications (0.06%) requiring care beyond the recovery room, with no cases of paralysis or death 4.

Required Risk Counseling

  • Shared decision-making must include discussion of potential complications: dural puncture, insertion-site infections, sensorimotor deficits, cauda equina syndrome, spinal cord injury, and rare catastrophic neurological complications 3, 2.

  • Local anesthetic systemic toxicity (LAST) is a rare but documented complication that can occur with delayed onset (up to 50 minutes post-injection), requiring monitoring in the post-procedure period 6.

Anesthesia and Sedation Considerations

Moderate Sedation (CPT 99152,99153)

  • Moderate sedation for cervical epidural injection is reasonable for patient comfort, particularly when performing multi-level injections or in anxious patients.

  • The procedure itself (interlaminar cervical epidural) is typically performed with local anesthetic infiltration at the skin entry site, and moderate sedation adds an additional layer of patient comfort 4.

Anesthesia Code 01992

  • This anesthesia code for therapeutic nerve blocks in the cervical region is appropriate when moderate sedation or monitored anesthesia care is provided during the procedure.

Common Pitfalls to Avoid

  • Do not perform cervical epidural injections for non-radicular neck pain alone: The procedure is specifically indicated for radiculopathy with nerve root involvement, not for axial neck pain from facet arthropathy or myofascial pain 1.

  • Do not proceed without imaging correlation: MRI findings must match the clinical presentation and radicular distribution 3, 2.

  • Do not perform without documented conservative treatment failure: At minimum, 4 weeks of appropriate non-interventional care should be attempted first 3.

  • Do not perform without fluoroscopic guidance: This is a mandatory safety requirement for cervical epidural injections 3, 2, 4.

Evidence Quality Assessment

  • The recommendation for cervical epidural steroid injection in radiculopathy is supported by multiple professional society guidelines including the American Society of Anesthesiologists and American College of Physicians 3, 1, 2.

  • While definitive evidence of efficacy from randomized controlled trials is limited, available studies demonstrate favorable results with acceptable safety profiles when proper technique is used 7, 8.

  • A Turkish study of 58 patients with symptomatic cervical radiculopathy showed treatment success rates of 93% at 1 month, 86% at 3 months, and 72% at 6 months, with significant reduction in surgical rates 8.

This Procedure is NOT Experimental

  • Cervical epidural steroid injection is an established, guideline-supported treatment modality for cervical radiculopathy that has been used for several decades 7, 8.

  • The procedure is recognized by major professional societies and is considered standard of care when appropriate patient selection criteria are met 3, 1, 2.

References

Guideline

Medical Necessity for Transforaminal Epidural Injection in Spondylosis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Lumbar Transforaminal Epidural Steroid Injections for Radiculopathy

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Determination of Medical Necessity for Initial Lumbar Epidural Steroid Injection in Patients with Chronic Low Back Pain

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Epidural steroid injections for cervical radiculopathy.

Physical medicine and rehabilitation clinics of North America, 2011

Research

[Cervical epidural steroid injections for symptomatic disc herniations].

Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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