What is the difference between Aquaphor (petrolatum) and Vaseline (petrolatum)?

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Last updated: April 5, 2025View editorial policy

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From the Guidelines

Aquaphor is generally recommended over Vaseline for managing skin conditions due to its additional ingredients that promote healing and provide extra hydration. When considering the management of congenital ichthyoses, a study published in the British Journal of Dermatology in 2019 1 suggests that emollients, such as white petrolatum (Vaseline), can decrease transepithelial water loss (TEWL) but may increase the risk of cutaneous infections and impair sweating. In contrast, water-in-oil emollients like Aquaphor may be a preferable alternative. Key points to consider when choosing between Aquaphor and Vaseline include:

  • Application technique: using latex-free gloves and single-use packets can help avoid contamination
  • Risk of percutaneous absorption: avoiding active substances like urea, salicylic acid, or silver sulfadiazine is crucial
  • Daily bathing: advisable before ointment application to maintain skin hygiene
  • Skin type: considering the potential for petroleum allergies when selecting a product. Overall, while both products have their uses, Aquaphor's additional ingredients and potential for reduced risk of cutaneous infections make it a better choice for managing damaged or irritated skin.

From the Research

Comparison of Aquaphor and Vaseline

  • Aquaphor and Vaseline are two popular moisturizing products used to treat dry skin conditions such as xerosis cutis and atopic dermatitis.
  • According to a study on the diagnosis and treatment of xerosis cutis 2, suitable skin care products should be chosen with a view to improving skin hydration and restoring its barrier function, which is a key feature of both Aquaphor and Vaseline.
  • However, there is no direct comparison between Aquaphor and Vaseline in the provided studies, as they focus on the treatment of atopic dermatitis and xerosis cutis in general.

Ingredients and Effects

  • A study on the treatment of xerosis cutis 2 suggests that ingredients such as urea, ceramides, and natural moisturizing components can be effective in treating dry skin.
  • Vaseline, also known as petroleum jelly, is a common ingredient used to lock in moisture and protect the skin, while Aquaphor is a multi-purpose ointment that provides a breathable barrier to help repair dry, cracked skin.
  • Another study on xerosis 3 highlights the importance of restoring physiologic lipids in the epidermis and providing substances that facilitate epidermal differentiation, which may be relevant to the effects of Aquaphor and Vaseline.

Treatment of Dry Skin Conditions

  • The provided studies focus on the treatment of atopic dermatitis and xerosis cutis, with recommendations for maintenance therapy, topical corticosteroids, and other treatments 4, 5, 6.
  • While Aquaphor and Vaseline may be used as part of a treatment plan for dry skin conditions, there is no specific evidence in the provided studies to support their use or compare their effectiveness.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Diagnosis and treatment of xerosis cutis - a position paper.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2019

Research

[Xerosis: a dysfunction of the epidermal barrier].

Actas dermo-sifiliograficas, 2008

Research

Atopic Dermatitis: Diagnosis and Treatment.

American family physician, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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