Domperidone Dosing for a 5.8 kg Child
I cannot provide a dosing recommendation for domperidone in this child because none of the provided evidence contains any information about domperidone dosing in pediatric patients.
Critical Gap in Evidence
The evidence provided consists entirely of:
- Influenza antiviral medication guidelines (amantadine, rimantadine, zanamivir, oseltamivir) 1
- Acetaminophen dosing for children >40 kg 2
- Antacid use in adolescents 3
- Dexamethasone dosing guidelines 4
- Adult domperidone pharmacology and use in chronic dyspepsia, Parkinson's disease, and diabetic gastropathy 5, 6, 7, 8, 9
What is Missing
No guideline, drug label, or research evidence provided addresses:
- Pediatric domperidone dosing by weight
- Domperidone syrup concentration or formulation
- Age restrictions for domperidone use in children
- Safety data for domperidone in infants weighing 5.8 kg
Clinical Context from Available Evidence
While the adult literature describes domperidone as a dopamine antagonist with antiemetic and prokinetic properties that has minimal CNS penetration 5, 7, 9, and one source mentions "control of cytotoxic-induced and postprandial nausea and vomiting in children has been achieved with domperidone without evidence of extrapyramidal side effects" 5, no specific pediatric dosing information is provided in any of the evidence.
To safely prescribe domperidone syrup for this 5.8 kg child, you must consult:
- The FDA-approved drug label or product monograph
- Current pediatric gastroenterology or formulary references
- Institutional pediatric dosing protocols