From the Research
Magnesium bisglycinate can generally be taken by people on statins, hypertension medications, and thyroid medications, but consultation with a healthcare provider is essential before starting. This form of magnesium is often better tolerated than other forms due to its higher absorption and reduced gastrointestinal side effects. For most adults, a typical dose ranges from 200-400mg of elemental magnesium daily, preferably divided into smaller doses with meals. However, timing matters - magnesium should be taken at least 2 hours apart from levothyroxine (thyroid medication) as it can interfere with absorption, as suggested by general medical knowledge and not explicitly stated in the provided studies 1, 2, 3, 4, 5.
Key Considerations
- Magnesium may complement statin therapy by potentially helping with muscle symptoms, as noted in a study comparing the effects of Mg2 and statin medications on lipoproteins 4.
- People with kidney disease should be particularly cautious with magnesium supplementation as impaired kidney function can lead to dangerous magnesium accumulation in the body, a consideration that is crucial for patient safety.
- The combination of increased intake of magnesium and potassium coupled with reduced sodium intake is more effective in reducing blood pressure than single mineral intake, as observed in a study on the role of magnesium in hypertension and cardiovascular disease 1.
- Magnesium also increases the effectiveness of all antihypertensive drug classes, which is an important factor in managing hypertension 1.
Important Interactions
- Separate magnesium intake from certain blood pressure medications like hydrochlorothiazide by at least 2 hours to avoid potential interactions.
- Monitor for any changes in medication effectiveness when taking magnesium alongside statins or other medications.
- Consider the benefits of physical activity as a critical component of first-line treatment for elevated blood pressure or cholesterol, as recommended by the American Heart Association 5.
Final Recommendation
Given the potential benefits and considerations, it is recommended that individuals on statins, hypertension medications, and thyroid medications consult with a healthcare provider before starting magnesium bisglycinate supplementation, ensuring safe and effective management of their condition, as supported by the most recent and highest quality study available 4.