From the Research
Interaction between Caffeine and Sildenafil
- There are no research papers provided to directly answer the question about the interaction between caffeine and sildenafil (Viagra) 1, 2, 3, 4, 5.
- The studies provided focus on the interaction between sildenafil and other medications, such as antihypertensive drugs and organic nitrates, but do not mention caffeine.
- Sildenafil is known to have interactions with certain medications, such as nitrates, which can lead to potentiation of decreases in blood pressure and potentially life-threatening hypotension 1, 4, 5.
- However, without specific studies on the interaction between caffeine and sildenafil, it is not possible to determine the effects of concomitant use of these substances.
Sildenafil Mechanism and Interactions
- Sildenafil works by selectively inhibiting phosphodiesterase type 5, allowing corpus cavernosum smooth muscle to relax and potentiating erections during sexual stimulation 3, 4.
- The drug has been shown to be effective in treating erectile dysfunction, with common adverse events including headache, flushing, dyspepsia, and abnormal vision 2, 3, 5.
- Sildenafil has been found to have additive, but not synergistic, effects on blood pressure when used with certain antihypertensive medications, such as calcium antagonists 4.