From the Guidelines
The ICD-10 code for Mycoplasma genitalium infection is A56.3, which specifically represents "Other sexually transmitted chlamydial infections" but since there is no specific code exclusively for Mycoplasma genitalium, A49.3 "Mycoplasma infection, unspecified site" can be used as an alternative. When documenting this condition, it's essential to clearly specify "Mycoplasma genitalium" in the clinical notes to distinguish it from other mycoplasma species, as noted in the context of urological infections guidelines 1. If the infection has manifested with specific symptoms or at particular anatomical sites, additional codes may be used to document these manifestations, such as codes for urethritis (N34.1) or cervicitis (N72) if present. Mycoplasma genitalium is increasingly recognized as an important cause of non-gonococcal urethritis in men and cervicitis, pelvic inflammatory disease, and potentially infertility in women, making accurate coding important for proper tracking and treatment of this infection, with treatment options including Azithromycin as a first-line therapy 1. Key considerations in managing Mycoplasma genitalium infections include the potential for macrolide resistance, in which case alternative treatments like Moxifloxacin may be necessary 1. Accurate diagnosis and coding are crucial for guiding appropriate treatment and for epidemiological tracking of this sexually transmitted infection.
From the Research
Mycoplasma Genitalium Infection
- Mycoplasma genitalium infection is a sexually transmitted infection that can cause urethritis, cervicitis, and pelvic inflammatory disease (PID) 2, 3, 4.
- The infection is typically diagnosed through nucleic acid amplification testing (NAAT) and can be treated with antibiotics such as azithromycin, doxycycline, and moxifloxacin 2, 3, 5.
ICD-10 Code for Mycoplasma Genitalium Infection
- The ICD-10 code for Mycoplasma genitalium infection is A74.0, which is classified under "Other sexually transmitted diseases" [2 is not directly relevant to ICD-10 codes, but 3 and other studies discuss the infection].
Treatment Options
- Azithromycin is a commonly used treatment for Mycoplasma genitalium infection, with a cure rate of 85-95% in macrolide-susceptible infections 2.
- Doxycycline has a cure rate of 30-40%, but resistance is not increasing 2.
- Moxifloxacin can be used as second-line therapy, but resistance is increasing 2, 5, 4.
- Pristinamycin and solithromycin may be of clinical benefit for multidrug-resistant infections 5.
Resistance and Treatment Failure
- Macrolide resistance is a growing concern in the treatment of Mycoplasma genitalium infection, with reports of treatment failure and resistance emerging worldwide 3, 5, 6.
- The use of azithromycin 1g single dose is associated with high rates of treatment failure and development of macrolide resistance 6.
- The 5-day azithromycin regimen may be more effective and less likely to cause resistance, but more studies are needed to confirm this 6.