From the Research
There are potential contraindications between Excedrin Migraine and tadalafil (Cialis) that you should be aware of, particularly related to increased bleeding risk and hypotension, and it is recommended to consult with your healthcare provider before taking these medications together. Excedrin Migraine contains aspirin, acetaminophen, and caffeine, and the aspirin component can increase bleeding risk, which may be a concern when combined with tadalafil 1. More importantly, the combination could potentially cause dangerous drops in blood pressure. Tadalafil, like other erectile dysfunction medications, works by dilating blood vessels, and when combined with aspirin (which has mild blood pressure-lowering effects), this could lead to hypotension, dizziness, fainting, or headaches.
Some key points to consider when evaluating the safety of this combination include:
- The risk of bleeding associated with aspirin in Excedrin Migraine, which could be exacerbated by tadalafil 2
- The potential for hypotension due to the vasodilatory effects of tadalafil and the mild blood pressure-lowering effects of aspirin 3
- The importance of consulting with a healthcare provider to evaluate individual risk factors and medical history before taking these medications together 4
It is essential to note that the most recent and highest quality study on this topic, published in 2022, highlights the importance of considering cardiovascular safety concerns when managing migraine, particularly in patients with comorbid diseases such as depression, epilepsy, stroke, and myocardial infarction 1. Therefore, it is crucial to prioritize caution and consult with a healthcare provider before taking Excedrin Migraine and tadalafil together.