Brexul DS and Sleep Effects
There is no evidence that the antibiotic "Brexul DS" causes sleep or sedation. The medication you're asking about appears to be confused with brexpiprazole (a psychiatric medication), but no antibiotic by the name "Brexul DS" exists in standard medical literature or the evidence provided.
Critical Clarification
No antibiotic called "Brexul DS" is documented in any of the available medical literature, FDA databases, or clinical guidelines provided 1, 2, 3, 4, 5.
The evidence references only discuss brexpiprazole (an antipsychotic/antidepressant adjunct) and brexucabtagene autoleucel (a CAR T-cell therapy for leukemia), neither of which are antibiotics 1, 2, 3, 5.
If You Meant Brexpiprazole (Not an Antibiotic)
Brexpiprazole actually improves sleep disturbances rather than causing excessive sedation in patients with major depressive disorder 1.
Sleep Effects of Brexpiprazole:
- Improves sleep efficiency by 10.4 percentage points on polysomnography and increases total sleep time by 49 minutes 1.
- Reduces sleep onset latency by 19.7 minutes and wake time after sleep onset by 26.4 minutes 1.
- Decreases daytime sleepiness as measured by the Epworth Sleepiness Scale (improvement of -2.1 points) 1.
- Insomnia Severity Index improved by -9.2 points after 8 weeks of treatment 1.
Adverse Effects Related to Sleep:
- In elderly patients with Alzheimer's dementia, insomnia occurred in 5.7% of patients on brexpiprazole 2 mg/day versus 4.4% on placebo 5.
- Somnolence occurred in 6.1% of patients on flexible-dose brexpiprazole (0.5-2 mg/day) versus 3.6% on placebo 5.
Common Pitfall to Avoid
Do not confuse medication names—verify the exact generic and brand name of any medication before counseling patients about side effects. If you're looking for information about a specific antibiotic, please confirm the correct spelling and generic name, as "Brexul DS" does not correspond to any known antibiotic formulation 1, 2, 3, 4, 5.