What is the diagnosis for a patient presenting with a sore throat and white exudates on the tonsils, but no fever (pyrexia)?

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Last updated: April 6, 2025 • View editorial policy

Differential Diagnosis for Sore Throat with White Exudates on Tonsils and No Fever

  • Single Most Likely Diagnosis + Streptococcal pharyngitis (caused by Group A beta-hemolytic streptococcus): This condition is a common cause of sore throat and can present with white exudates on the tonsils. Although fever is often present, its absence does not rule out the diagnosis.
  • Other Likely Diagnoses + Viral pharyngitis: Many viruses can cause pharyngitis, and some may present with exudates on the tonsils. The absence of fever might lean more towards a viral etiology, but it's not definitive. + Mononucleosis (infectious mononucleosis): Caused by Epstein-Barr virus, this condition can present with sore throat, exudates on the tonsils, and might not always have a high fever, especially in the early stages.
  • Do Not Miss Diagnoses + Diphtheria: Although rare in areas with good vaccination coverage, diphtheria is a serious infection that can cause a sore throat and a membrane or exudate on the tonsils. It's crucial to consider this diagnosis due to its potential severity and the importance of prompt treatment. + Lemierre's syndrome: This is a rare but serious condition that starts with pharyngitis and can progress to septicemia and thrombophlebitis of the internal jugular vein. The initial presentation might not include fever, but it's a diagnosis that could have severe consequences if missed.
  • Rare Diagnoses + Mycoplasma pneumoniae infection: While more commonly associated with lower respiratory tract infections, Mycoplasma pneumoniae can cause pharyngitis. The presentation might include sore throat and could potentially have exudates, though this is less common. + Gonococcal pharyngitis: Neisseria gonorrhoeae can cause pharyngitis, which might present with sore throat and exudates. This diagnosis is important to consider, especially in sexually active individuals, due to its implications for contact tracing and treatment. + Syphilitic pharyngitis: Caused by Treponema pallidum, this condition is a rare cause of sore throat and can present in various stages of syphilis. It's an important diagnosis to consider due to its implications for treatment and public health.

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