Can Suboxone (buprenorphine and naloxone) films be cut?

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Last updated: April 6, 2025View editorial policy

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From the Research

Yes, Suboxone films can be cut into smaller pieces, specifically into half fractions, for dose adjustments, but this should only be done under a healthcare provider's guidance, using a ruler and razor to ensure accurate dosing, as evidenced by the study published in the International Journal of Pharmaceutical Compounding in 2019 1. When cutting Suboxone films, it is essential to handle them with dry hands and place them immediately under the tongue or inside the cheek after cutting to minimize exposure to air, which can reduce the medication's effectiveness. The study found that cutting Suboxone films into half fractions using a ruler and razor method resulted in acceptable weight variation and content uniformity, with both active ingredients retaining more than 97.7% of their initial strength over 7 days when stored in polybags at room temperature 1. Some key points to consider when cutting Suboxone films include:

  • Using a ruler and razor to cut the film into half fractions
  • Handling the film with dry hands to prevent moisture from affecting the medication
  • Placing the cut film immediately under the tongue or inside the cheek to minimize exposure to air
  • Discussing any dose changes with a healthcare provider before modifying the prescribed regimen It is crucial to prioritize proper cutting and handling techniques to ensure consistent medication delivery and optimal treatment outcomes for opioid dependence, as Suboxone contains buprenorphine (a partial opioid agonist) and naloxone (an opioid antagonist), and maintaining the correct dose is vital for managing withdrawal symptoms and cravings.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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