From the Research
There are no significant contraindications between Vyvanse (lisdexamfetamine) and tadalafil when taken together, but caution is advised due to potential additive effects on blood pressure. Both medications can affect cardiovascular function in different ways - Vyvanse may increase blood pressure and heart rate as a stimulant medication used for ADHD and binge eating disorder, while tadalafil, used for erectile dysfunction or pulmonary hypertension, works as a vasodilator that can lower blood pressure. When combined, these opposing cardiovascular effects could theoretically balance out, but in some individuals might cause problems with blood pressure regulation.
- Patients with pre-existing cardiovascular conditions, hypertension, or hypotension should be particularly careful and monitor their blood pressure when using these medications together.
- It's essential to inform your healthcare provider about all medications you're taking, including these, so they can monitor for potential interactions and adjust dosages if necessary.
- If you experience symptoms like severe headache, dizziness, fainting, or chest pain while taking these medications together, seek medical attention immediately. According to a study published in the Journal of central nervous system disease 1, Lisdexamfetamine dimesylate has demonstrated a safety profile consistent with long-acting stimulants use, with small mean increases seen in blood pressure and pulse rate in patients receiving LDX. Another study published in CNS drugs 2 also reported that the safety and tolerability profile of LDX in individuals with ADHD is similar to that of other stimulants. However, a study published in Frontiers in pharmacology 3 found that lisdexamfetamine and D-amphetamine produced similar peak increases in mean arterial blood pressure, heart rate, body temperature, pupil size, and adverse effects.
- The pharmacokinetics and pharmacodynamics of lisdexamfetamine are similar to D-amphetamine administered 1h later 3.
- Lisdexamfetamine is likely associated with a similar risk of oral abuse as D-amphetamine 3. Other studies, such as those published in The Cochrane database of systematic reviews 4 and Heart (British Cardiac Society) 5, discuss the importance of exercise in preventing coronary heart disease, but do not provide direct evidence related to the interaction between Vyvanse and tadalafil.