What are the rates of reduction in menstrual blood loss and amenorrhea with Kyleena (levonorgestrel-releasing) intrauterine device (IUD)?

From the Guidelines

Kyleena IUD reduces menstrual blood loss and increases amenorrhea rates over time, with approximately half of users likely to experience amenorrhea or oligomenorrhea by 2 years of use. The reduction in menstrual blood loss and increase in amenorrhea rates are due to the local effects of the progestin hormone levonorgestrel, which thins the uterine lining, resulting in lighter periods or sometimes no periods at all 1. Some users may experience irregular bleeding or spotting during the first 3-6 months after insertion, which usually stabilizes over time 2. Key benefits of Kyleena IUD include:

• Reduction in menstrual blood loss over time
• Increase in amenorrhea rates, with approximately half of users experiencing amenorrhea or oligomenorrhea by 2 years of use
• Local effects of levonorgestrel, which thins the uterine lining, resulting in lighter periods or sometimes no periods at all
• No permanent effect on fertility, with normal menstrual cycles typically returning quickly after removal.

From the Research

Reduction in Menstrual Blood Loss with Kyleena IUD

• The studies provided do not specifically mention the Kyleena IUD, but rather the levonorgestrel-releasing intrauterine system (LNG-IUS) 3, 4, 5, 6, 7.
• According to the studies, the LNG-IUS has been shown to reduce menstrual blood loss (MBL) in women with heavy menstrual bleeding (HMB) or menorrhagia 3, 4, 5, 6, 7.
• The reduction in MBL with LNG-IUS use has been reported to be significant, with decreases ranging from 74% to 97% 7.
• One study found that MBL decreased by -84.5% after 3 months, -92.9% after 6 months, and -93.8% after 1 year of LNG-IUS use 5.
• Another study reported that menorrhagia was reduced in 89% of women by 3 months, and all women had no menorrhagia by 6 months, with 39% of women becoming amenorrheic 4.

Amenorrhea Rates with Kyleena IUD

• As with the reduction in menstrual blood loss, the studies provided do not specifically mention the Kyleena IUD, but rather the LNG-IUS 3, 4, 5, 6, 7.
• According to the studies, the LNG-IUS has been shown to induce amenorrhea in a significant proportion of women with HMB or menorrhagia 4, 6.
• One study reported that 39% of women became amenorrheic after 6 months of LNG-IUS use 4.
• Another study found that 18 patients (28.57%) developed amenorrhea after using the LNG-IUS for menorrhagia 6.