What is the steroid dosage for pulmonary hemorrhage in leptospirosis?

From the Research

Steroid Dosage for Pulmonary Hemorrhage in Leptospirosis

• The exact steroid dosage for pulmonary hemorrhage in leptospirosis is not clearly stated in the provided studies 1, 2, 3, 4, 5.
• However, some studies suggest the use of high-dose corticosteroids in cases of severe pulmonary involvement due to leptospirosis 2, 3, 5.
• One study used methyl prednisolone pulse therapy in patients with leptospiral pulmonary alveolar hemorrhage 3.
• Another study used a single bolus of corticoids to rapidly control diffuse alveolar hemorrhage and myositis in a patient with icterohemorrhagic leptospirosis 5.
• The study 3 also used cyclophosphamide, an immunosuppressive agent, in addition to corticosteroids, and found it to be useful in improving survival in cases of severe pulmonary alveolar hemorrhage due to leptospirosis.

Treatment Protocols

• The treatment protocols used in the studies included:
  • Glucocorticoids 1, 2, 3, 5
  • Cyclophosphamide 3
  • Antibiotics such as penicillin and omacycline 4
  • Veno-venous extracorporeal membrane oxygenation (VV-ECMO) 4
  • Anti-inflammatory agents and high-dose vasoactive drugs 4
• The studies suggest that a combination of these treatments may be effective in managing pulmonary hemorrhage in leptospirosis, but the optimal treatment protocol is not clearly established 1, 2, 3, 4, 5.