Ozempic Dosing Frequency
Yes, Ozempic (semaglutide) is dosed once weekly via subcutaneous injection. 1
Administration Schedule
Ozempic is administered subcutaneously once weekly, on the same day each week, at any time of day, with or without meals. 1
The weekly dosing schedule can be adjusted if necessary, as long as there are at least 2 days (>48 hours) between consecutive doses. 1
Semaglutide has a half-life of approximately 7 days, which allows for the once-weekly dosing regimen and results in steady-state concentrations being reached in 4-5 weeks. 2
Dosing Titration
Treatment begins with 0.25 mg subcutaneously once weekly for 4 weeks (this initial dose is for treatment initiation and is not effective for glycemic control). 1
After 4 weeks, the dose increases to 0.5 mg once weekly. 1
If additional glycemic control is needed after at least 4 weeks on the 0.5 mg dose, the dosage may be increased to 1 mg once weekly (the maximum FDA-approved dose for diabetes). 1
For weight loss indications, the maintenance dose is 2.4 mg once weekly, reached through gradual titration over 16 weeks. 3, 4
Missed Dose Management
If a dose is missed and it has been less than 5 days since the scheduled dose, administer as soon as possible. 1
If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. 1
After addressing a missed dose, patients resume their regular once-weekly dosing schedule. 1
Injection Sites
Administer subcutaneously to the abdomen, thigh, or upper arm, using a different injection site each week when injecting in the same body region. 1
When using Ozempic with insulin, administer as separate injections and never mix the products, though both can be injected in the same body region if not adjacent to each other. 1