Daflon Dosing for Adults
For adults with chronic venous insufficiency or hemorrhoidal disease, the recommended dose of Daflon 500 mg is 2 tablets (1000 mg total) daily. 1, 2, 3
Standard Dosing Regimen
- Chronic Venous Insufficiency: Daflon 500 mg, 2 tablets daily for 60 days, typically given as a single daily dose 1, 2
- Hemorrhoidal Disease (Acute Episodes): Daflon 500 mg, 2 tablets twice daily (4 tablets total = 2000 mg/day) for 4 weeks during acute flares 3, 4
- Hemorrhoidal Disease (Chronic Symptoms): Daflon 500 mg, 2 tablets daily for 2 months 3
Clinical Context and Evidence
The dosing differs based on the condition being treated. For venous insufficiency and venous ulcer healing, the standard regimen is 1000 mg daily (2 tablets of 500 mg) for 60 days, which has been shown in randomized trials to accelerate venous ulcer healing when combined with elastic compression 1. This micronized flavonoid formulation allows for once-daily dosing with excellent tolerability 2.
For hemorrhoidal disease, the dosing is more aggressive during acute episodes. A double-blind, placebo-controlled trial demonstrated that 2 tablets twice daily (2000 mg/day) for 2 months significantly reduced the frequency of acute attacks (40% vs 70% in placebo), shortened attack duration (2.6 vs 4.6 days), and decreased symptom severity 3. A subsequent study in Saudi patients confirmed efficacy with 2 tablets twice daily for 4 weeks, showing statistically significant improvement in pain, bleeding, pruritus, and proctoscopic appearance 4.
Important Considerations
- Tolerability: Daflon demonstrates excellent safety with minimal side effects; gastrointestinal symptoms occur in approximately 5% of patients but rarely require discontinuation 4
- Treatment Duration: The standard course is 2 months for both venous insufficiency and hemorrhoidal disease 1, 3
- Combination Therapy: For venous ulcers, Daflon should be used in addition to elastic compression, not as monotherapy 1
Note: The question mentions "Almitrine" in the expanded context, but this appears to be an error. Almitrine is a respiratory stimulant (50-100 mg/day for COPD) 5, while Daflon is a micronized purified flavonoid fraction used for venous disease. The evidence provided and clinical use clearly indicate these are different medications with different indications.