Differential Diagnosis for Throat Irritation at Night with Cough
- Single Most Likely Diagnosis
- Gastroesophageal Reflux Disease (GERD): This condition is characterized by the backflow of stomach acid into the esophagus, which can cause throat irritation and cough, especially at night when lying down. The sensation of something coming up is consistent with acid reflux.
- Other Likely Diagnoses
- Postnasal Drip: Mucus from the nose can drip down the back of the throat, causing irritation and cough, especially at night. This is a common condition that can be exacerbated by allergies or a cold.
- Asthma: Nocturnal asthma can cause cough and throat irritation, especially if triggered by allergens or irritants in the bedroom.
- Upper Respiratory Infection: A viral or bacterial infection can cause throat irritation and cough, which may worsen at night.
- Do Not Miss Diagnoses
- Lung Cancer: Although less likely, lung cancer can cause cough and throat irritation, especially if the tumor is located in the upper airways. It's essential to consider this diagnosis, especially in smokers or those with a significant smoking history.
- Pulmonary Embolism: A blood clot in the lungs can cause sudden onset of cough and chest pain, which may worsen at night. This is a life-threatening condition that requires immediate attention.
- Rare Diagnoses
- Eosinophilic Esophagitis: A rare condition characterized by inflammation of the esophagus, which can cause throat irritation, cough, and difficulty swallowing.
- Foreign Body Aspiration: Although more common in children, adults can also accidentally inhale objects, which can cause cough and throat irritation.
- Angioedema: A rare condition that causes swelling of the airways, which can lead to throat irritation, cough, and difficulty breathing.