Differential Diagnosis for Elevated Platelet Count with Purpura and Hidradenitis
- Single most likely diagnosis
- Essential Thrombocythemia: This condition is characterized by an elevated platelet count and can lead to purpura due to abnormal platelet function. Hidradenitis, although not a direct consequence, can be associated with inflammatory conditions that may also contribute to thrombocytosis.
- Other Likely diagnoses
- Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause thrombocytosis as a reactive process and may also be associated with skin manifestations such as purpura and hidradenitis due to inflammation and autoimmunity.
- Rheumatoid Arthritis: This autoimmune disease can lead to elevated platelet counts and may cause purpura through vasculitis. Hidradenitis could be related to the overall inflammatory burden.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Thrombotic Thrombocytopenic Purpura (TTP): Although TTP typically presents with thrombocytopenia, some variants or early stages might show elevated platelet counts. The presence of purpura is a key feature, and hidradenitis, while uncommon, could be part of a broader spectrum of systemic symptoms.
- Malignancy (e.g., Lymphoma): Certain cancers can cause paraneoplastic syndromes leading to elevated platelet counts and may also be associated with skin manifestations like purpura and hidradenitis.
- Rare diagnoses
- Myeloproliferative Neoplasms (other than Essential Thrombocythemia): Conditions like Polycythemia Vera or Primary Myelofibrosis can also present with elevated platelet counts and, less commonly, with purpura and hidradenitis.
- Sjögren's Syndrome: This autoimmune disorder can lead to a variety of systemic symptoms, including elevated platelet counts, purpura, and potentially hidradenitis, although the latter is less common.