Can Vraylar (Cariprazine) Cause Diarrhea?
No, diarrhea is not a recognized adverse effect of Vraylar (cariprazine) based on available clinical trial data and drug approval information. The provided evidence does not identify gastrointestinal disturbances, including diarrhea, as a notable side effect of this atypical antipsychotic medication.
Evidence Review
Cariprazine is a dopamine D3-preferring D2/D3 receptor partial agonist approved for schizophrenia and bipolar I disorder (manic or mixed episodes) 1
In clinical trials spanning 6-week acute treatment studies and long-term relapse prevention trials, cariprazine demonstrated a favorable tolerability profile with most adverse events being mild to moderate in severity 2
The available clinical data does not list diarrhea among the common or significant adverse effects of cariprazine 1, 2
Metabolic changes observed with cariprazine were generally not clinically significant, and gastrointestinal side effects were not highlighted as concerns in the drug's development or approval process 2
Clinical Context
While the evidence provided extensively discusses drug-induced diarrhea from various medication classes—including chemotherapy agents 3, 4, immunosuppressants 3, antibiotics 4, 5, and other medications 5, 6, 7—cariprazine is not mentioned among the medications known to cause diarrhea.
Important Caveat
If a patient taking Vraylar develops diarrhea, consider alternative causes such as: