Liquid Amphetamine Formulations
ProCentra (dextroamphetamine sulfate oral solution) is the primary liquid amphetamine formulation available, supplied as a 5 mg/5 mL bubblegum-flavored oral solution. 1
Available Liquid Formulation
- ProCentra is the FDA-approved liquid dextroamphetamine product, available as a 5 mg/5 mL oral solution in 16-fluid-ounce containers. 1
- This liquid formulation allows for precise dose titration and is particularly useful in pediatric populations or patients who have difficulty swallowing tablets. 2
Important Clinical Considerations
- Liquid dextroamphetamine is a short-acting formulation that provides dosing flexibility but carries a higher risk of rebound effects compared to long-acting formulations. 2
- The typical starting dose for immediate-release dextroamphetamine (Dexedrine) is 5 mg twice daily, which can be easily measured and adjusted with the liquid formulation. 2
Formulations NOT Available as Liquids
- Adderall (mixed amphetamine salts) is not available in liquid form—it comes only as immediate-release tablets or extended-release capsules (Adderall XR). 2, 3
- Lisdexamfetamine (Vyvanse) is available only as capsules, not as a liquid formulation. 4, 5
- Lisdexamfetamine is a prodrug that requires hydrolysis in the blood to release active d-amphetamine, and alternative routes of administration do not bypass this requirement effectively. 4
Common Adverse Effects
- All amphetamine formulations, including liquid dextroamphetamine, share common adverse effects: decreased appetite, sleep disturbances, increased blood pressure and pulse, headaches, irritability, and stomach pain—generally mild and temporary. 2
- Liquid formulations should be administered in the morning to minimize sleep disturbances. 3