What is the treatment for mastitis?

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Treatment of Lactational Mastitis

Continue breastfeeding or milk expression on the affected breast while initiating antibiotic therapy targeting Staphylococcus aureus, specifically dicloxacillin or cephalexin as first-line agents. 1, 2

Immediate Management Steps

Continue Breastfeeding

  • Regular feeding or milk expression from the affected breast is essential and must be encouraged even during active mastitis. 1, 2
  • Breastfeeding can safely continue even if an abscess has formed, provided the infant's mouth does not contact purulent drainage from the breast. 1
  • Discontinuing breastfeeding worsens the condition and increases risk of abscess formation. 1
  • Effective milk removal is the most critical component of treatment and may make antibiotics unnecessary in some cases. 3

Antibiotic Therapy

  • Dicloxacillin or cephalexin are the preferred first-line antibiotics, as they effectively target Staphylococcus aureus, the most common causative organism. 2, 3
  • Dicloxacillin/cloxacillin transfer minimally into breast milk, making them safe during breastfeeding. 3
  • As methicillin-resistant S. aureus (MRSA) becomes more prevalent, antibiotics effective against MRSA may become necessary if initial therapy fails. 2
  • One small trial comparing amoxicillin with cephradine showed no significant difference, though evidence suggests faster symptom clearance with antibiotics versus supportive therapy alone. 4, 1

Supportive Care

  • Provide appropriate analgesics for pain management, as pain can exacerbate symptoms. 1
  • Address mechanical factors: optimize breastfeeding technique and latch, often requiring consultation with a lactation specialist. 2
  • Ensure frequent, complete breast emptying to prevent milk stasis. 2

When to Hospitalize

Hospitalization is warranted when fever and chills indicate systemic involvement, or when there is concern for sepsis. 1

During hospitalization:

  • Provide access to breast pumps if prolonged separation from infant occurs. 1
  • Ensure availability of trained breastfeeding support staff. 1
  • Schedule procedures to allow breastfeeding or milk expression as close to surgery as possible. 1

Management of Complications

Breast Abscess

  • Approximately 10% of mastitis cases progress to breast abscess, which requires drainage via surgical intervention or needle aspiration. 1, 2
  • Early treatment of mastitis and continued breastfeeding prevent abscess formation. 2
  • Breastfeeding can continue on the affected side even with a treated abscess, as long as the infant's mouth avoids purulent drainage. 1, 2

Common Pitfalls to Avoid

  • Never advise stopping breastfeeding during mastitis treatment—this is the most critical error and will worsen the condition. 1
  • Do not delay antibiotic treatment when systemic symptoms are present, as this increases abscess risk. 1
  • Milk culture is necessary to determine the infecting organism and antibiotic sensitivity when initial therapy fails. 3
  • Address underlying causes such as poor latch, sore nipples, or infant mouth anomalies that precipitate mastitis. 2

References

Guideline

Inpatient Management of Mastitis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Management of mastitis in breastfeeding women.

American family physician, 2008

Research

[Treatment of mastitis in general practice].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003

Research

Antibiotics for mastitis in breastfeeding women.

The Cochrane database of systematic reviews, 2013

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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