What is the dosing schedule for Trulicity (dulaglutide)?

From the Guidelines

Trulicity (dulaglutide) should be administered as a once-weekly subcutaneous injection, with a standard starting dose of 0.75 mg once weekly, which can be increased to 1.5 mg once weekly for additional glycemic control if needed, as recommended in the Mayo Clinic Proceedings study 1. The dosing schedule for Trulicity is as follows:

• Initially, 0.75 mg once weekly at any time of day
• If additional glycemic control is required, can increase to 1.5 mg once weekly The injection can be administered at any time of day, with or without meals, and should be given on the same day each week. Key points to consider when administering Trulicity include:
• The medication comes in a pre-filled pen device that doesn't require dose measuring or needle handling
• If a dose is missed, it should be administered as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose; otherwise, skip the missed dose and administer the next dose on the regularly scheduled day
• Trulicity works by mimicking the incretin hormone GLP-1, which stimulates insulin secretion, inhibits glucagon release, and slows gastric emptying, helping to control blood sugar levels in people with type 2 diabetes, as described in the study 1.

From the FDA Drug Label

2 DOSAGE AND ADMINISTRATION

2.1 Adult Dosage The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly. Increase the dosage to 1.5 mg once weekly for additional glycemic control. If additional glycemic control is needed, increase the dosage in 1.5 mg increments after at least 4 weeks on the current dosage. The maximum recommended dosage is 4.5 mg injected subcutaneously once weekly.

2.2 Pediatric Dosage The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly. If additional glycemic control is needed, increase the dosage to the maximum recommended dosage of 1.5 mg once weekly after at least 4 weeks on the 0.75 mg dosage.

2.3 Recommendations Regarding Missed Dose If a dose is missed, instruct patients to administer the dose as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose. If less than 3 days remain before the next scheduled dose, skip the missed dose and administer the next dose on the regularly scheduled day In each case, patients can then resume their regular once weekly dosing schedule.

The dosing schedule for Trulicity is as follows:

• Adult Dosage:
  • Starting dosage: 0.75 mg subcutaneously once weekly
  • Increase to 1.5 mg once weekly for additional glycemic control
  • Further increase in 1.5 mg increments after at least 4 weeks on the current dosage
  • Maximum recommended dosage: 4.5 mg subcutaneously once weekly
• Pediatric Dosage:
  • Starting dosage: 0.75 mg subcutaneously once weekly
  • Increase to 1.5 mg once weekly after at least 4 weeks on the 0.75 mg dosage for additional glycemic control
• Missed Dose:
  • Administer the missed dose as soon as possible if there are at least 3 days until the next scheduled dose
  • Skip the missed dose if less than 3 days remain before the next scheduled dose 2 2

From the Research

Dosing Schedule for Trulicity

• The dosing schedule for Trulicity (dulaglutide) is once weekly, as a subcutaneous injection 3.
• Trulicity is administered via injection, with a recommended dose of 1.5 mg once weekly 4.
• The once-weekly dosing schedule of Trulicity is similar to other long-acting GLP-1 receptor agonists, such as semaglutide and albiglutide 5.
• The dosing schedule of Trulicity may be adjusted based on individual patient needs and response to treatment, but the standard dosing schedule is once weekly 4.