From the Guidelines
Estroven supplements are not recommended for hot flashes due to limited evidence on their efficacy and safety, particularly in women with a history of breast cancer 1. The use of Estroven, which typically contains black cohosh and soy isoflavones, has been studied in various contexts, but the most recent and highest quality evidence suggests that these supplements do not provide significant relief from hot flashes 2, 1. In fact, studies have shown that black cohosh may be of no benefit in reducing hot flashes, and there have been reports of liver failure associated with its use 2. Other non-hormonal treatments, such as venlafaxine, paroxetine, and gabapentin, have been found to be effective in reducing hot flashes in women with breast cancer, and may be considered as alternative options 3, 4. Key considerations for managing hot flashes include:
- Assessing the severity of symptoms and patient preferences
- Considering non-hormonal treatment options, such as venlafaxine, paroxetine, and gabapentin
- Evaluating the safety and efficacy of any treatment, particularly in women with a history of breast cancer
- Monitoring for potential side effects and adjusting treatment as needed. It is essential to consult with a healthcare provider to determine the best course of treatment for hot flashes, taking into account individual needs and medical history.
From the Research
Estroven Supplements for Hot Flashes
- Estroven is a dietary supplement that contains black cohosh, an herbal remedy often used to alleviate menopausal symptoms, including hot flashes 5, 6.
- The effectiveness of black cohosh in reducing hot flashes has been studied in several clinical trials, with mixed results 7, 5, 6.
- A 2006 study found that black cohosh did not significantly reduce hot flash frequency or severity compared to a placebo 7.
- In contrast, a 2004 pilot study suggested that black cohosh may be effective in reducing hot flashes, with a 50% reduction in mean daily hot flash frequency 5.
- A 2012 systematic review of 16 randomized controlled trials found that black cohosh was not significantly more effective than placebo in reducing hot flashes or menopausal symptom scores 6.
- The review also noted that the quality of the included trials was generally unclear due to inadequate reporting, and that further studies are needed to fully assess the effectiveness and safety of black cohosh for menopausal symptoms 6.
- Another review published in 2003 concluded that the evidence for the effectiveness of black cohosh in treating hot flashes is conflicting, and that larger and longer studies are needed to detect potential adverse events 8.
- Hormone replacement therapy (HRT) is considered the gold standard for managing vasomotor and vaginal symptoms of menopause, including hot flashes, but it carries significant risks, such as stroke, cardiovascular disease, and breast cancer 9.