Scopolamine Brand Names
Scopolamine is most commonly available as Transderm Scōp (transdermal patch formulation) in the United States, which is the primary brand name for the transdermal therapeutic system. 1
Available Formulations
Transdermal Patch
- Transderm Scōp is the branded transdermal patch containing 1.5 mg of scopolamine with a programmed delivery of 0.5 mg over a 3-day period 2
- The patch includes a priming dose of 140 mcg incorporated into the adhesive layer to accelerate achievement of steady-state blood levels 2
- Releases scopolamine at approximately 5 mcg/hour 2
Other Formulations
- Scopolamine is also available in oral tablets, capsules, oral solutions, and injectable forms, though these are less commonly used due to shorter duration of action and higher incidence of adverse effects 2, 3
- The transdermal system was specifically developed to counter the adverse effects and short duration of action that restricted usefulness of oral or parenteral scopolamine 2
Clinical Context
Primary Indication
- The transdermal patch formulation was initially developed and FDA-approved for prevention of motion sickness 2, 4
- Subsequently approved in 2001 for prevention of postoperative nausea and vomiting (PONV) 4
Off-Label Uses
- Used off-label for management of excessive secretions (including post-CVA secretions and end-of-life care), though this lacks formal clinical study support 1
- Applied off-label in gastroparesis for nausea management, despite lack of supporting clinical studies 1
Important Prescribing Information
Dosing and Application
- Standard dose is 1.5 mg patch applied to the postauricular area 1
- Should be applied at least 6-8 hours before the anti-motion sickness effect is required 2
- Each patch is effective for 72 hours (3 days), after which it should be removed and a new one applied behind the opposite ear 2