From the FDA Drug Label
ADVERSE REACTIONS Anticholinergics, including glycopyrrolate injection, can produce certain effects, most of which are extensions of their pharmacologic actions Adverse reactions may include ... decreased sweating; ... dry skin, and other dermal manifestations; WARNINGS ... in the presence of fever, high environmental temperature and/or during physical exercise, heat prostration can occur with use of anticholinergic agents including glycopyrrolate (due to decreased sweating), particularly in children and the elderly.
The FDA drug label does not answer the question.
From the Research
Glycopyrrolate cream is generally considered safe to use on hands, feet, and other body areas affected by hyperhidrosis, with the most recent and highest quality study supporting its efficacy and safety 1. When using glycopyrrolate cream, it is essential to follow proper application guidelines to minimize side effects.
- Apply a thin layer to clean, dry skin
- Wash your hands afterward unless they are the treatment area
- Typical concentrations range from 1-2%, applied once or twice daily
- Side effects are usually mild and localized, including skin dryness, irritation, or redness
- Systemic side effects like dry mouth, blurry vision, or urinary retention are less common with topical application compared to oral glycopyrrolate but can occur if the cream is applied to large body areas The cream works by blocking acetylcholine receptors in sweat glands, thereby reducing sweat production.
- For best results, apply at night when sweating is typically reduced
- If you experience significant side effects or inadequate relief, consult your healthcare provider about adjusting the concentration or exploring alternative treatments It is crucial to note that while glycopyrrolate cream is considered safe, individual results may vary, and patients should be monitored for any adverse effects 2, 3.
- A study published in 2017 found that low-dose glycopyrrolate may be a safe and effective method of controlling exertional hyperhidrosis 1
- Another study published in 2008 demonstrated the efficacy and safety of topical glycopyrrolate for patients with facial hyperhidrosis 2
- Additionally, a 2003 study showed that topical glycopyrrolate can be an effective treatment for gustatory hyperhidrosis 3