What is the maximum dose of Humulin 500 (insulin lispro) that can be injected at once from a pen?

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Maximum Dose for Humulin R U-500 Pen

The Humulin R U-500 pen delivers insulin in 5-unit increments with a maximum single injection dose of 300 units per injection. 1

Device Specifications

  • U-500 pens dispense in 5-unit dose increments, which is different from standard U-100 pens that typically use 1-unit or 0.5-unit increments 1
  • The maximum dose that can be dialed and injected in a single administration from the U-500 pen is 300 units 2
  • Each U-500 pen cartridge contains 1,500 units total (3 mL at 500 units/mL concentration), allowing for multiple injections before the pen is depleted 3

Clinical Context for U-500 Use

U-500 insulin is specifically indicated for patients requiring more than 200 units of insulin per day, typically those with severe insulin resistance 4, 5

Key advantages of U-500:

  • Reduces injection volume by 80% compared to U-100 insulin (same dose in one-fifth the volume) 3, 6
  • Functions as both basal and prandial insulin due to its prolonged pharmacodynamic profile 3, 7
  • Can be administered as a convenient twice-daily regimen as monotherapy 4
  • Improves patient compliance by reducing the number of injections needed 4, 6

Critical Safety Considerations

Dosing Errors - Major Pitfall

  • The 5-unit increment means each click delivers 5 units, not 1 unit - this is the most common source of dangerous dosing errors 1
  • Patients and providers must understand that dialing "10" on a U-500 pen delivers 50 units, not 10 units 2
  • Never use U-100 syringes to draw up U-500 insulin from vials, as this leads to five-fold overdosing 3

Pharmacodynamic Properties

  • Onset of action is delayed 2.5+ hours after injection, making U-500 unsuitable as a premeal bolus for immediate postprandial glucose control 7
  • Duration of action extends with higher doses - 200-unit doses last significantly longer than 100-unit doses 7
  • This prolonged action necessitates extended dosing intervals to avoid stacking doses and causing hypoglycemia 7

Common Adverse Effects

  • Hypoglycemia risk increases with U-500 use, particularly when transitioning from U-100 insulins 4, 5
  • Weight gain is a consistent side effect 4
  • Symptomatic hypoglycemia events increase modestly (from 2.0 to 3.3 events per patient per year) after U-500 initiation 5

Proper Injection Technique

When administering any dose from the U-500 pen:

  • Prime the pen before each injection to ensure unobstructed flow 2
  • Insert needle fully into subcutaneous tissue before pressing the dose button 2
  • Keep pressure on the button until the needle is completely withdrawn to prevent incomplete dosing 2
  • Dispose of needles immediately after use; never leave attached to the pen 2
  • Never share pens between patients due to contamination risk 2

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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