Can an electrocardiogram (EKG) be ordered for palpitations?

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Last updated: December 17, 2025View editorial policy

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Can an EKG be Ordered for Palpitations?

Yes, a 12-lead electrocardiogram (EKG/ECG) is mandatory and should be obtained immediately in all patients presenting with palpitations. 1, 2, 3

Why the 12-Lead ECG is Essential

The resting 12-lead ECG serves multiple critical diagnostic functions that directly guide management decisions:

  • Identifies baseline rhythm abnormalities including pre-excitation patterns (Wolff-Parkinson-White syndrome), conduction defects, and signs of structural heart disease 2, 3
  • Detects life-threatening patterns such as QT prolongation, Brugada pattern, signs of hypertrophic cardiomyopathy, prior infarction, or ventricular hypertrophy 3
  • Determines if immediate specialist referral is needed: The presence of pre-excitation on resting ECG with a history of paroxysmal regular palpitations is sufficient for presumptive diagnosis of atrioventricular reentrant tachycardia (AVRT) and warrants immediate referral to cardiac electrophysiology without needing to document the arrhythmia first 1, 2

Critical Pitfall to Avoid

Do not rely on automatic ECG analysis systems - they are unreliable and commonly suggest incorrect arrhythmia diagnoses. 1, 2 Manual interpretation by a physician is required.

When the Initial ECG Shows Pre-Excitation

This finding changes everything:

  • Regular palpitations + pre-excitation = presumptive AVRT → immediate electrophysiology referral 1, 2
  • Irregular palpitations + pre-excitation = atrial fibrillation with accessory pathway → requires immediate electrophysiological evaluation due to risk of sudden death 1, 2

Beyond the Initial ECG

If the resting 12-lead ECG doesn't capture the arrhythmia, ambulatory monitoring is the next step:

  • For frequent/daily palpitations: 24-48 hour Holter monitoring 1, 3
  • For weekly episodes: External event recorder or wearable loop recorder for 2-4 weeks 3
  • For infrequent episodes (monthly or less): Implantable loop recorder should be considered when no cause is identified after prolonged ECG monitoring 1, 3

The European Society of Cardiology specifically recommends 48-hour ambulatory ECG monitoring as first-line for patients with frequent or sustained palpitations to identify the likely cause. 1, 3

What to Look for on the ECG

Examine specifically for:

  • Pre-excitation (delta waves suggesting WPW syndrome) 3
  • QT interval prolongation 3
  • Brugada pattern 3
  • Left ventricular hypertrophy or signs of hypertrophic cardiomyopathy 3
  • Q waves suggesting prior myocardial infarction 3
  • Bundle branch blocks or other conduction abnormalities 2, 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Palpitations: Differential Diagnosis and Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Diagnostic Approach to Palpitations

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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