Are Tessalon Perls (Benzonatate) safe in chronic obstructive pulmonary disease (COPD) exacerbation?

From the Research

Safety of Tessalon Perls (Benzonatate) in COPD Exacerbation

There is no direct evidence in the provided studies regarding the safety of Tessalon Perls (Benzonatate) in chronic obstructive pulmonary disease (COPD) exacerbation. However, we can look at the general management and treatment of COPD exacerbations:

• The management of COPD exacerbations includes the use of short-acting bronchodilators, antibiotics, and a short course of oral prednisolone 1.
• Exacerbations are often triggered by respiratory viral infections and/or bacterial infections, and several pharmacologic therapies can prevent COPD exacerbations and reduce hospital admissions 2.
• Nonpharmacologic interventions for exacerbation prevention include pulmonary rehabilitation, long-term oxygen therapy, and home noninvasive ventilator support 2.

Relevant Information on Benzodiazepines

Although not directly related to Benzonatate, a study on benzodiazepine use among older adults with COPD found that:

• Benzodiazepines have been linked to adverse physiological respiratory outcomes in individuals with COPD 3.
• The potential adverse respiratory effects of benzodiazepines in COPD may be heightened in older adults due to altered pharmacokinetics 3.

COPD Exacerbation Management

Key points in managing COPD exacerbations include:

• Identifying and treating exacerbations promptly to reduce morbidity and mortality 4.
• Using a supported self-management plan to help patients understand and act on exacerbations 1.
• Balancing prompt treatment with careful antibiotic and corticosteroid stewardship 1.