Is Uriexo effective for urinary conditions?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: December 18, 2025 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Is Uriexo (Uro-Vaxom) Effective for Urinary Conditions?

Yes, Uro-Vaxom (OM-89) is effective and recommended for preventing recurrent urinary tract infections in women, with strong evidence showing it reduces UTI recurrence for 6-12 months compared to placebo. 1

Evidence for Effectiveness

Guideline-Level Recommendations

  • The 2018 Journal of Urology guidelines on recurrent UTI treatment explicitly state that Uro-Vaxom is safe and effective in reducing UTI recurrence for 6 to 12 months compared to placebo, based on meta-analyses of randomized controlled trials. 1

  • The 2024 European Association of Urology guidelines give a strong recommendation to use immunoactive prophylaxis (which includes Uro-Vaxom) to reduce recurrent UTI in all age groups. 1

Clinical Trial Evidence

  • A high-quality double-blind RCT of 120 patients showed that Uro-Vaxom significantly decreased the number of UTI recurrences, total antibiotic consumption, bacteriuria, and dysuria compared to placebo over 6 months, with protective effects lasting an additional 5 months after treatment cessation. 2

  • A 2025 systematic review confirmed that Uro-Vaxom decreased UTI recurrence, was well-tolerated, and reduced the need for antibiotic therapies, though it noted methodological limitations in some included studies. 3

Mechanism and Dosing

  • Uro-Vaxom is an oral vaccine containing a lyophilized lysate of 18 selected Escherichia coli strains that triggers immunity through increased lymphocyte and macrophage activity. 1

  • Longer protection (beyond 6-12 months) may be achieved with 3 monthly 10-day booster courses. 1

Clinical Context and Positioning

When to Use Uro-Vaxom

  • Use Uro-Vaxom as part of a stepwise approach to recurrent UTI prevention: first counsel on risk factor avoidance, then try non-antimicrobial measures (including immunoactive prophylaxis), and reserve continuous antimicrobial prophylaxis for when these interventions fail. 1

  • For postmenopausal women, vaginal estrogen replacement receives a strong recommendation and should be prioritized alongside or before Uro-Vaxom. 1

Antibiotic Stewardship Benefits

  • A critical advantage of Uro-Vaxom is reducing antibiotic exposure, which is essential given that fluoroquinolones and cephalosporins cause significant collateral damage to fecal microbiota and increase Clostridium difficile infection risk. 1

  • By the sixth month of treatment in clinical trials, patients receiving Uro-Vaxom were consuming no antibiotics, compared to ongoing antibiotic use in placebo groups. 2

Safety Profile

  • Uro-Vaxom is safe with a low rate of adverse events, with only mild side effects reported in approximately 3% of patients (4 out of 120 in one trial). 1, 2

Important Caveats

  • The available evidence focuses almost exclusively on women; data in men are limited. 3

  • While effective, the retrospective nature of several studies and variability in study design prevent precise quantification of treatment effect magnitude. 3

  • Uro-Vaxom is available in Europe but may not be accessible in all countries, including the United States where it is not FDA-approved.

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Related Questions

What is the recommended management for colonization after a Urinary Tract Infection (UTI)?
What is the appropriate management for a 17-year-old female with recurrent urinary tract infections?
What is the appropriate treatment for an elderly female with abdominal pain, trace leukocytes, and a history of recurrent Urinary Tract Infections (UTIs), with a urine dip negative for nitrites?
What antibiotic is recommended for prophylactic treatment of urinary tract infections (UTIs)?
Is there conservative management for urinary tract infection (UTI)?
What is the best course of action for an elderly male patient with end-stage kidney disease (ESKD) on dialysis, recently diagnosed with bilateral exophytic masses on the kidneys and bilateral hydronephrosis?
Would you initiate Clostridioides difficile (C. diff) prophylaxis (PPX) treatment in a patient with an active C. diff infection, a history of C. diff, and currently on antibiotics?
What was the incidence of measles encephalitis (inflammation of the brain caused by measles) in children in the USA before the introduction of the Measles, Mumps, and Rubella (MMR) vaccine?
How is drug-induced parkinsonism best managed?
What imaging, aside from brain MRI (Magnetic Resonance Imaging) with contrast, is critical in the evaluation of a 4-year-old with progressive facial asymmetry?
What is the typical vocabulary size for an 18-month-old child?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.

Ask Question