What is most expected to be decreased in a trauma patient who has lost 25% of their blood volume?

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Answer: Pulse Pressure (Option B)

In a trauma patient who has lost 25% of their blood volume (Class II hemorrhagic shock), pulse pressure is the parameter most expected to be decreased among the options provided. 1

ATLS Classification Framework

According to the American College of Surgeons Advanced Trauma Life Support (ATLS) classification, a 25% blood volume loss corresponds to Class II hemorrhagic shock (15-30% blood loss). 1

Expected Physiological Changes in Class II Hemorrhage:

Pulse pressure: Decreased 1

Urine output: 20-30 mL/hour (still maintained, though reduced from normal >30 mL/hour) 1

Respiratory rate: 20-30 breaths/minute (increased, not decreased) 1

Mental status: Mildly anxious (Glasgow Coma Scale typically preserved) 1

Why Pulse Pressure Decreases First

Pulse pressure narrows in Class II hemorrhage due to compensatory mechanisms: 1

  • Sympathetic activation causes peripheral vasoconstriction, elevating diastolic blood pressure 1
  • Systolic blood pressure remains normal or slightly reduced in Class II shock 1
  • The narrowing gap between systolic and diastolic pressures (pulse pressure) serves as an early indicator of hypovolemia before frank hypotension develops 1

Analysis of Other Options

Urine output (Option A): While reduced to 20-30 mL/hour in Class II hemorrhage, it does not become severely decreased until Class III (5-15 mL/hour) or negligible until Class IV. 1 At 25% blood loss, urine output is maintained through compensatory mechanisms. 1

Respiratory rate (Option C): This parameter increases (20-30 breaths/minute) rather than decreases in Class II hemorrhage as a compensatory response to maintain tissue oxygenation. 1 Hyperventilation is common in trauma patients during resuscitation. 1

Glasgow Coma Scale (Option D): Mental status in Class II hemorrhage is characterized as "mildly anxious" with preserved consciousness. 1 Significant GCS deterioration occurs in Class III (anxious, confused) and Class IV (confused, lethargic) hemorrhage. 1

Clinical Pitfalls to Avoid

Do not rely solely on blood pressure for assessment: Blood pressure remains normal in Class II hemorrhage despite significant blood loss due to compensatory mechanisms. 1, 2 Pulse pressure narrowing is a more sensitive early indicator. 1

Recognize the progression pattern: As hemorrhage advances from Class II to Class III (30-40% loss), urine output drops dramatically to 5-15 mL/hour, respiratory rate increases further to 30-40 breaths/minute, and mental status deteriorates. 1

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Expected Blood Loss in Severe Hemorrhagic Shock

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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