Does Vitamin D influence coagulation?

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Last updated: April 7, 2025View editorial policy

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From the Research

Vitamin D does have an influence on blood clotting, though its effects are complex and not fully understood, with recent evidence suggesting no definitive link between vitamin D deficiency and a prothrombotic profile 1. The relationship between vitamin D and blood clotting is multifaceted, with vitamin D potentially having both pro-coagulant and anti-coagulant properties.

  • Vitamin D can increase the production of certain clotting factors in the liver, which could theoretically promote clotting.
  • It also has anti-inflammatory effects that may reduce the risk of abnormal clotting.
  • Vitamin D deficiency has been associated with increased risk of both bleeding disorders and thrombotic events (unwanted blood clots) 2.
  • However, a systematic review found no definitive link between vitamin D deficiency and a prothrombotic profile, suggesting that the relationship between vitamin D and blood clotting is more complex than previously thought 1. The recommended daily intake of vitamin D for most adults is 600-800 IU, with blood levels ideally maintained between 30-50 ng/mL.
  • People taking blood thinners like warfarin should maintain consistent vitamin D levels, as significant fluctuations could potentially affect the medication's efficacy.
  • The relationship between vitamin D and clotting is particularly relevant for individuals with conditions like deep vein thrombosis or those at risk for cardiovascular events, though more research is needed to fully understand these connections 3, 4.

References

Research

Is Vitamin D Deficiency Prothrombotic? A Systematic Review.

Seminars in thrombosis and hemostasis, 2023

Research

Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study.

Sao Paulo medical journal = Revista paulista de medicina, 2021

Research

Vitamin D and cardiovascular health.

Clinical nutrition (Edinburgh, Scotland), 2021

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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