From the Research
Role of Sermorelin in Anti-Aging
- Sermorelin, a 29 amino acid analogue of human growth hormone-releasing hormone (GHRH), stimulates growth hormone secretion from the anterior pituitary 1.
- Growth hormone (GH) secretion declines with aging, and GHRH has been investigated as a potential therapeutic agent to promote physical and psychological function in older adults 2, 3.
- GHRH treatment has been shown to increase lean body mass, reduce body fat, and improve certain tests of cognitive performance in older adults 2, 4.
- The use of GHRH or its analogs may be an alternative mode for restoring the GH-IGF-I axis in aging individuals, with potential benefits for body composition and metabolism 3, 4.
Effects of Sermorelin on Body Composition and Metabolism
- Sermorelin treatment has been shown to increase skin thickness and lean body mass in men, with a trend towards a positive nitrogen balance in both men and women 4.
- GHRH analog administration has been found to increase insulin sensitivity in men, but not in women 4.
- The effects of sermorelin on body composition and metabolism may vary by gender, with men appearing to respond more favorably to treatment 4.
Potential Therapeutic Applications of Sermorelin
- Sermorelin may have a therapeutic role in promoting growth in children with idiopathic growth hormone deficiency 1.
- GHRH and its analogs may have potential applications in the treatment of adult GH deficiency and normal aging 2, 3, 5.
- Further studies are needed to fully elucidate the effects of sermorelin and GHRH on body composition, metabolism, and overall health in different populations 2, 4.