What additional assessments should be included in the examination of a 42-year-old woman with sudden weight gain, fatigue, and menorrhagia (heavy menses)?

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From the Guidelines

For this 42-year-old woman with sudden weight gain, fatigue, and heavy menses, additional assessments should include a pelvic ultrasound or MRI to evaluate for uterine fibroids, as well as a complete blood count to assess for anemia related to heavy menstrual bleeding, as suggested by the most recent guidelines 1. Given her symptoms of heavy and prolonged uterine bleeding, a thorough physical examination, including an abdominal examination, speculum examination, and bimanual pelvic evaluation, is essential to characterize the location, shape, and mobility of any potential fibroids. Additional workup may include:

  • Pregnancy testing to rule out pregnancy as a cause of her symptoms
  • Hemoglobin levels to evaluate the severity of anemia
  • Endometrial biopsy if features of her presentation raise concern for other causes of heavy menstrual bleeding, such as endometrial hyperplasia or cancer
  • Assessment of her reproductive history, including age of menarche, regularity of menses, and history of difficulty getting pregnant, to evaluate for any underlying reproductive disorders
  • Screening for thyroid dysfunction, as her family history of thyroid problems and symptoms of fatigue and weight gain may suggest hypothyroidism, with a comprehensive thyroid panel (TSH, free T3, free T4, and thyroid antibodies) 1
  • Evaluation of her mental health, given her history of depression, to assess for any exacerbation of symptoms due to potential underlying medical conditions. These assessments are crucial because they can help identify the underlying cause of her symptoms, whether it be uterine fibroids, thyroid dysfunction, or another condition, and allow for timely and appropriate management to improve her quality of life and prevent complications.

From the Research

Additional Assessments for Patient Examination

The patient's symptoms of sudden and unexpected weight gain, fatigue, and heavy menses for the past 3 months require a comprehensive assessment. The following additional assessments should be included in the patient examination:

  • Vital signs assessment, including calculation of Body Mass Index (BMI) as a vital sign 2
  • A complete physical examination to obtain valid information concerning the patient's health, including evaluation of individual organ systems 3
  • Assessment of the patient's condition, including how they are responding to medical treatment and whether the patient is deteriorating 4
  • General health checks to identify and prevent disease, including screening for chronic diseases such as depression and hypertension 5
  • Evaluation of the patient's medical history, including their history of allergies, Guillain-Barré syndrome, depression, and difficulty getting pregnant
  • Review of the patient's family medical history, including their maternal grandmother's history of thyroid problems

Key Principles of Vital Signs Assessment

The assessment of vital signs is critical for safe, high-quality care 4. The following key principles should be considered:

  • Vital signs data provide valuable insight into the patient's condition
  • Abnormal vital signs have been associated with poor clinical outcomes
  • Factors contributing to neglected vital signs assessment include nurses' knowledge, clinical judgement, culture, tradition, and workloads

General Health Checks in Adult Primary Care

General health checks are commonly performed in adult primary care to identify and prevent disease 5. The following points should be considered:

  • General health checks are not associated with decreased mortality, cardiovascular events, or cardiovascular disease incidence
  • General health checks are associated with increased detection of chronic diseases, moderate improvements in controlling risk factors, and increased clinical preventive service uptake
  • Primary care teams may reasonably offer general health checks, especially for groups at high risk of overdue preventive services, uncontrolled risk factors, low self-rated health, or poor connection or inadequate access to primary care 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Essentials of a complete physical examination.

Clinics in podiatric medicine and surgery, 1998

Research

The global elements of vital signs' assessment: a guide for clinical practice.

British journal of nursing (Mark Allen Publishing), 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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