Insufficient Information to Provide a Specific Recommendation
The question asks about taking "cream" at 4 mg six days a week and 5 mg one day a week, but no specific medication or clinical indication is identified, making it impossible to provide evidence-based guidance on this dosing regimen.
Why This Question Cannot Be Answered
The provided evidence does not address this specific dosing pattern for any topical medication. The evidence base includes:
Topical corticosteroid guidelines that recommend twice-daily application of various potency steroids for dermatological conditions, but dosing is described by frequency of application (e.g., "b.i.d." or twice daily), not by milligram amounts per day 1
Systemic medication dosing for conditions like psoriasis, onychomycosis, and migraine, which use oral or injectable routes—not topical creams 1
Topical antifungal treatments measured by percentage concentration (e.g., 1% clotrimazole cream, 5% amorolfine lacquer) applied at specified frequencies, not by absolute milligram doses 1
Critical Information Needed
To provide appropriate guidance, the following information is essential:
- What specific medication/cream is being referenced (generic and brand name)
- What condition is being treated
- Patient characteristics (age, weight, comorbidities)
- Why this unusual dosing pattern (4 mg × 6 days, then 5 mg × 1 day) is being considered
General Principles for Topical Medications
Topical medications are typically dosed by application frequency and amount (grams), not by milligrams per day 1. For example, emollients for patients on EGFR-TKI therapy are recommended at 200-400 g per week with twice-daily dosing 1.
Variable daily dosing of topical preparations is not a standard practice in dermatology based on the available guideline evidence 1.
Please clarify the specific medication and clinical indication to receive appropriate evidence-based guidance.