Octaplex Concentration in 100 mL Solution
Octaplex is supplied as a powder for reconstitution, and when reconstituted with 100 mL of solvent, it contains 500 IU of Factor IX activity per 100 mL (equivalent to 5 IU/mL). 1, 2
Standard Vial Configurations
Octaplex vials contain 500 IU of Factor IX when reconstituted with the accompanying 100 mL of solvent, resulting in a concentration of 5 IU Factor IX per mL 1, 3
The product is a four-factor prothrombin complex concentrate containing balanced amounts of vitamin K-dependent coagulation factors (Factors II, VII, IX, and X) in physiological ratios 4
Clinical Dosing Context
For warfarin reversal, Octaplex is typically dosed at 25-50 IU/kg body weight based on INR levels:
For direct Factor Xa inhibitor reversal, a fixed dose of 2,000 units (400 mL of reconstituted solution) is reasonable for severe or life-threatening bleeding 5
Studies have used doses ranging from 15-83 IU/kg body weight, with median doses of 20-41 IU/kg showing effective INR correction 1, 2, 4
Volume Calculations
A 1,000 IU dose requires 200 mL of reconstituted Octaplex solution 3
For a 70 kg patient requiring 35 IU/kg (2,450 IU total), approximately 490 mL of reconstituted solution would be needed 5
The 40 mL standard dose used in some protocols delivers approximately 200 IU Factor IX 3
Administration Characteristics
Onset of action occurs within 10 minutes of intravenous administration, with INR correction typically achieved within 1 hour 1, 4
Single dose administration is sufficient in 95% of cases for effective reversal 2
The product can be administered via intraosseous route if intravenous access is difficult 5